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Molecular development

Sequencing Therapy for Optimal Response in Mirikizumab (STORM)-study: A tertiary referral center study on patients with therapy-refractory ulcerative colitis

Alica Kubesch, Raul Lande, Anna Leutgöb, Karima Farrag, Iulia Dahmer, Katharina Stratmann-Vollrath, Antje Dienethal, Florian Alexander Michael, Kathrin Sprinzl, Stefan Zeuzem, Irina Blumenstein

published 24 Oct 2025

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Anti-inflammatory effect of bergamot leaves extract attenuates cardiac remodeling in obese rats by regulating the protein expression of the collagen/metalloproteinase axis

Taynara Aparecida Vieira, Juliana Silva Siqueira, Erika Tiemi Nakandakare-Maia, Nubia Alves Grandini, Marina Gaiato Monte, Giovanna Baron, Dijon Henrique Salomé de Campos, Giancarlo Aldini, Silmeia Garcia Zanati Bazan, Fabiane Valentini Francisqueti-Ferron, Lilian Cristina Pereira, Marina Politi Okoshi, Francis Lopes Pacagnelli, Artur Junio Togneri Ferron, Camila Renata Corrêa

published 24 Oct 2025

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Chronic companions: An updated national cross-sectional study of metabolic syndrome comorbidities in outpatient visits for hidradenitis suppurativa

Elaine J. Ma, Alyssa M. Roberts, Peichi Chou, Abigail Katz, Charlotte Y. Jeong, Yvonne Nong, Maria T. Ochoa, April W. Armstrong

published 24 Oct 2025

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Curcumin attenuates LPS-induced inflammation in RAW 264.7 cells: A multifaceted study integrating network pharmacology, molecular docking, molecular dynamics simulation, and experimental validation

Xiaojing Gong, Dingshan Xue, Hongyan Meng, Bing Xie, Lihua Zhao, Chuanhui Zang, Jingjing Kong

published 23 Oct 2025

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A mathematical study for psoriasis transmission with immune-mediated time delays and optimal control strategies

Xianbing Cao, Subhankar Kushary, Tushar Ghosh, Fahad Al Basir, Priti Kumar Roy

published 17 Oct 2025

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Partial removal of visceral epididymal white adipose tissue in obese Ldlr-/-.Leiden mice impacts adipokine secretion, plasma free fatty acids, and improves cerebrovascular health

Florine Seidel, Martine C. Morrison, Ilse Arnoldussen, Vivienne Verweij, Simon Ebert, Joline Attema, Christa de Ruiter, Wim van Duyvenvoorde, Jessica Snabel, Bram Geenen, Ayla Franco, Eveline Gart, Jürgen Bernhagen, Maximilian Wiesmann, Robert Kleemann, Amanda J. Kiliaan

published 17 Oct 2025

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Comparison the impact of IFN-β alone or in combination with vitamin D on critical pathways involved in AML progression

Farzad Nasri, Hassan Jalaeikhoo, Maryam Dadmanesh, Nafiseh Behranvand, Reza Falak, Negin Hosseini Rouzbahan, Yalda Babaei, Khodayar Ghorban

published 16 Oct 2025

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Effects of a polypill on circulating levels of resistin and visfatin in men with non-alcoholic fatty liver disease: A five-year clinical trial

Mahdieh Nazari-Robati, Tania Dehesh, Beydolah Shahouzehi, Gholamreza Roshandel, Hossein Poustchi, Solaleh Emamgholipour

published 08 Oct 2025

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Revealing the molecular mechanisms underlying Xuebijing against sepsis and septic acute kidney injury via bioinformatics and experimental approaches

Xing Li, Kaiqi Ren, Michal R. Baran, Juan Tang, Le Wang, Gabriel Mbuta Tchivelekete, Yi Guo, Yang Bai, Weijian Yan, Xinhua Shu

published 03 Oct 2025

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Exploring local adjuvant antibiotics as viable alternative to systemic antibiotics in non-surgical periodontal therapy: Clinical, immunological and microbiological insights

Iva Milinkovic, Marija Vuckovic, Nadja Nikolic, Jelena Carkic, Zoran Aleksic, Sasha Jankovic, Jelena Milasin, Ana Djinic Krasavcevic

published 29 Sep 2025

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Ageing-driven molecular and functional changes in the bovine endometrium

Marine Denis, Doulaye Dembélé, Christophe Richard, Marie Leduc, Maud Pez, Pierrette Reinaud, Olivier Dubois, Hélène Kiefer, Hélène Jammes, Valérie Gelin, Fabienne Constant, François Vialard, Gilles Foucras, Pierre Germon, Gilles Charpigny, Olivier Sandra, Mariam Raliou

published 26 Sep 2025

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Identification and verification of hub biomarkers and immune-related pathways participating in the trabecular meshwork after using corticosteroid

Liwen Wang, Di Wu, Ziwei Ma, Di Song, Yuanqiang Sun, Xuefeng Pan, Junhui Zhang

published 25 Sep 2025

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Youthful systemic milieu in younger recipients alleviates acute kidney injury via attenuating apoptosis and oxidative stress in a rat kidney transplantation model

Chengjun Yu, Jie Zhang, Jun Pei, Shengde Wu, Sheng Wen, Yi Hua, Guanghui Wei

published 23 Sep 2025

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