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Molecular development

Myeloid Deletion of SIRT1 Aggravates Serum Transfer Arthritis in Mice via Nuclear Factor-κB Activation

Young-Sool Hah, Yun-Hong Cheon, Hye Song Lim, Hee Young Cho, Byung-Hyun Park, Sun-O Ka, Young-Rae Lee, Dong-Won Jeong, Hyun-Ok Kim, Myung-Kwan Han, Sang-Il Lee

published 03 Feb 2014

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The Candidate TB Vaccine, MVA85A, Induces Highly Durable Th1 Responses

Michele Tameris, Hennie Geldenhuys, Angelique KanyKany Luabeya, Erica Smit, Jane E. Hughes, Samantha Vermaak, Willem A. Hanekom, Mark Hatherill, Hassan Mahomed, Helen McShane, Thomas J. Scriba

published 03 Feb 2014

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Protective or Deleterious Role of Scavenger Receptors SR-A and CD36 on Host Resistance to Staphylococcus aureus Depends on the Site of Infection

Charlène Blanchet, Gregory Jouvion, Catherine Fitting, Jean-Marc Cavaillon, Minou Adib-Conquy

published 31 Jan 2014

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Enlarged Memory T-Cell Pool and Enhanced Th1-Type Responses in Chronic Myeloid Leukemia Patients Who Have Successfully Discontinued IFN-α Monotherapy

Mette Ilander, Anna Kreutzman, Peter Rohon, Teresa Melo, Edgar Faber, Kimmo Porkka, Jukka Vakkila, Satu Mustjoki

published 31 Jan 2014

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Targeting Innate Receptors with MIS416 Reshapes Th Responses and Suppresses CNS Disease in a Mouse Model of Multiple Sclerosis

Madeleine White, Gill Webster, David O’Sullivan, Sarrabeth Stone, Anne Camille La Flamme

published 31 Jan 2014

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Acquired Deficiency of A20 Results in Rapid Apoptosis, Systemic Inflammation, and Abnormal Hematopoietic Stem Cell Function

Akiko Nagamachi, Yuichiro Nakata, Takeshi Ueda, Norimasa Yamasaki, Yasuhiro Ebihara, Kohichiro Tsuji, Zen-ichiro Honda, Keiyo Takubo, Toshio Suda, Hideaki Oda, Toshiya Inaba, Hiroaki Honda

published 31 Jan 2014

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Astrocyte-Derived Proinflammatory Cytokines Induce Hypomyelination in the Periventricular White Matter in the Hypoxic Neonatal Brain

Yiyu Deng, Di Xie, Ming Fang, Gaofeng Zhu, Chunbo Chen, Hongke Zeng, Jia Lu, Kaur Charanjit

published 31 Jan 2014

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IL-12 Directs Further Maturation of Ex Vivo Differentiated NK Cells with Improved Therapeutic Potential

Dorit Lehmann, Jan Spanholtz, Caterina Sturtzel, Marleen Tordoir, Bernhard Schlechta, Dirk Groenewegen, Erhard Hofer

published 31 Jan 2014

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An In Silico Approach for Modelling T-Helper Polarizing iNKT Cell Agonists

Anton De Spiegeleer, Evelien Wynendaele, Matthias Vandekerckhove, Sofie Stalmans, Maxime Boucart, Nele Van Den Noortgate, Koen Venken, Serge Van Calenbergh, Sandrine Aspeslagh, Dirk Elewaut

published 31 Jan 2014

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Novel Pharmacologic Targeting of Tight Junctions and Focal Adhesions in Prostate Cancer Cells

Patrick J. Hensley, Andreas Desiniotis, Chi Wang, Arnold Stromberg, Ching-Shih Chen, Natasha Kyprianou

published 31 Jan 2014

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Phase I Clinical Trial of Fibronectin CH296-Stimulated T Cell Therapy in Patients with Advanced Cancer

Takeshi Ishikawa, Satoshi Kokura, Tatsuji Enoki, Naoyuki Sakamoto, Tetsuya Okayama, Mitsuko Ideno, Junichi Mineno, Kazuko Uno, Naohisa Yoshida, Kazuhiro Kamada, Kazuhiro Katada, Kazuhiko Uchiyama, Osamu Handa, Tomohisa Takagi, Hideyuki Konishi, Nobuaki Yagi, Yuji Naito, Yoshito Itoh, Toshikazu Yoshikawa

published 31 Jan 2014

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The Heme Oxygenase System Suppresses Perirenal Visceral Adiposity, Abates Renal Inflammation and Ameliorates Diabetic Nephropathy in Zucker Diabetic Fatty Rats

Joseph Fomusi Ndisang, Ashok Jadhav, Manish Mishra

published 30 Jan 2014

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The Modulation of Endoplasmic Reticulum Stress by Chemical Chaperone Upregulates Immune Negative Cytokine IL-35 in Apolipoprotein E-Deficient Mice

Bo Wang, Shen Dai, Zhaojing Dong, Yue Sun, Xingguo Song, Chun Guo, Faliang Zhu, Qun Wang, Lining Zhang

published 30 Jan 2014

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