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Molecular development

Chronic oral cannabidiol delays seizure onset and reduces seizure burden in a mouse model of CLN2 disease

Joshua T. Dearborn, Keigo Takahashi, Nicholas R. Rensing, Michael Wong, Jonathan D. Cooper, Mark S. Sands

published 20 Jul 2026

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12-HHT is associated with epithelial barrier enhancement and reduced inflammatory responses in colon organoids of normoganglionosis in Hirschsprung’s disease

Kazuto Suda, Kumpei Abe, Yurina Nishimura, Masafumi Tanaka, Yuki Nagasako, Xuxuan Rao, Jianqin Zhang, Siyi Zeng, Kentaro Fujiwara, Shunsuke Yamada, Junya Ishii, Shiho Yoshida, Soichi Shibuya, Go Miyano

published 16 Jul 2026

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Mycobacterial lipoarabinomannan negatively interferes with macrophage responses to Aspergillus fumigatus in-vitro

Luis E. Gonzales-Huerta, Thomas J. Williams, Renad Aljohani, Brian Robertson, Carlton A. Evans, Darius P. H. Armstrong-James

published 09 Jul 2026

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Lactiplantibacillus plantarum GUANKE alleviates Zearalenone-induced intestinal dysfunction by modulating oxidative stress and inflammation

Qiaoning Chang, Yanchao Zhao, Han Li, Bin Zhang, Meidi Zhang, Pei Zhao, Jingmin He, Bugao Li, Ming D. Li

published 01 Jul 2026

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Neuroprotective mechanisms of Thai traditional brain tonic Phy-Blica-O against LPS-induced neuroinflammation: Inhibition of NF-κB in microglia and mice

Thammarat Kaewmanee, Palanivel Ganesan, Piyapong Choochana, Pinanong Na-Phatthalung, Samuel Abiodun Kehinde, Sasitorn Chusri

published 26 Jun 2026

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TNFR2 is expressed by a discrete subset of epidermal T cells with an IL-17 gene signature during psoriasis

Jasmine Ahmed, Carolyn Matthews, Patricia Tulloch, William Lawler, Albert Mendoza, Mikaela Rhoiney, Julie M. Jameson

published 23 Jun 2026

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Effect of a freeze–thaw cycle on amniotic fluid interleukin-6 concentrations in pregnancies with preterm prelabor rupture of membranes: Implications for the diagnosis of intra-amniotic inflammation

Richard Spacek, Stepanka Bubenikova, Ivana Musilova, Nikola Kuzniciusova, Karolina Janochova, Michaela Kostelkova, Ladislava Pavlikova, Magdalena Holeckova, Marek Lubusky, Ondrej Simetka, Bo Jacobsson, Marian Kacerovsky

published 11 Jun 2026

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ICU-acquired infections and mortality in community-acquired pneumonia–induced sepsis: Insights from a transcriptomic analysis

Sultan Almuntashiri, Yazed S. Alsowaida, Duo Zhang, Ali Alghubayshi, Muteb Alanazi, Tareq Nafea Alharby, Mukhtar Ansari

published 05 Jun 2026

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Fasciola hepatica excretory-secretory products attenuate demyelination and reduce neuroinflammation in the Cuprizone –induced multiple sclerosis model

Aliakbar Mariki, Kristi Anne Kohlmeier, Seyed Mohammad Mousavi, Alireza Keyhani, Majid Fasihi Harandi, Mansoureh Sabzalizadeh, Mohammad Shabani

published 05 Jun 2026

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Dengue severity and profiles of complement activation and immune mediators: A multicenter cohort study in Indonesia

Ika Saptarini, Sri Masyeni, Alida Roswita Harahap, Astuti Giantini, Pringgodigdo Nugroho, Agus Handito, Harimat Hendarwan, Adityo Susilo, Sotianingsih Haryanto, Desi Fitriani, R. Tedjo Sasmono, Erni Juwita Nelwan

published 04 Jun 2026

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Comparison between enzyme-linked immunospot assay and intracellular cytokine flow cytometry assay of cytomegalovirus-specific T-cell response in healthy participants

Chompunuch Klinmalai, Nopporn Apiwattanakul, Somsak Prasongtanakij, Jackrapong Bruminhent, Supanart Srisala

published 04 Jun 2026

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Roflumilast prevented tissue damage caused by lipopolysaccharide-induced sepsis via anti-inflammatory action

Demet Yalçın Kehribar, Lale Saka Baraz, Seda Kırmızıkan, Emre Soner Tiryaki, Mustafa Nusret Çiçekli, Bahattin Avcı, Caner Günaydın

published 03 Jun 2026

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Study on the pathogenesis of PLXNB1 gene in olfactory dysfunction of allergic rhinitis

Xinglong Chen, Lingqiong Zhao, Wenlong Luo

published 01 Jun 2026

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