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Molecular development

The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD

Kirsty E. Russell, Kian Fan Chung, Colin J. Clarke, Andrew L. Durham, Patrick Mallia, Joseph Footitt, Sebastian L. Johnston, Peter J. Barnes, Simon R. Hall, Karen D. Simpson, Malcolm R. Starkey, Philip M. Hansbro, Ian M. Adcock, Coen H. Wiegman

published 11 Jan 2016

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Largescale Transcriptomics Analysis Suggests Over-Expression of BGH3, MMP9 and PDIA3 in Oral Squamous Cell Carcinoma

Yuan He, Fangyang Shao, Weidong Pi, Cong Shi, Yujia Chen, Diping Gong, Bingjie Wang, Zhiwei Cao, Kailin Tang

published 08 Jan 2016

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Dendritic Cells Induce a Subpopulation of IL-12Rβ2-Expressing Treg that Specifically Consumes IL-12 to Control Th1 Responses

Uri Sela, Chae Gyu Park, Andrew Park, Peter Olds, Shu Wang, Ralph M. Steinman, Vincent A. Fischetti

published 08 Jan 2016

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Toll-Like Receptor 4 Is Essential in the Development of Abdominal Aortic Aneurysm

Chao-Han Lai, Kuan-Chieh Wang, Fang-Tzu Lee, Hung-Wen Tsai, Chih-Yuan Ma, Tsung-Lin Cheng, Bi-Ing Chang, Yu-Jen Yang, Guey-Yueh Shi, Hua-Lin Wu

published 07 Jan 2016

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The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages

Arwa Abu Khweek, Apurva Kanneganti, Denis C. Guttridge D, Amal O. Amer

published 07 Jan 2016

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Tumor Necrosis Factor, but Not Neutrophils, Alters the Metabolic Profile in Acute Experimental Arthritis

Marina C. Oliveira, Luciana P. Tavares, Juliana P. Vago, Nathália V. Batista, Celso M. Queiroz-Junior, Angelica T. Vieira, Gustavo B. Menezes, Lirlândia P. Sousa, Fons A. J. van de Loo, Mauro M. Teixeira, Flávio A. Amaral, Adaliene V. M. Ferreira

published 07 Jan 2016

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Topical Formulation Containing Naringenin: Efficacy against Ultraviolet B Irradiation-Induced Skin Inflammation and Oxidative Stress in Mice

Renata M. Martinez, Felipe A. Pinho-Ribeiro, Vinicius S. Steffen, Thais C. C. Silva, Carla V. Caviglione, Carolina Bottura, Maria J. V. Fonseca, Fabiana T. M. C. Vicentini, Josiane A. Vignoli, Marcela M. Baracat, Sandra R. Georgetti, Waldiceu A. Verri Jr., Rubia Casagrande

published 07 Jan 2016

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Conformational Sampling and Binding Site Assessment of Suppression of Tumorigenicity 2 Ectodomain

Chao-Yie Yang, James Delproposto, Krishnapriya Chinnaswamy, William Clay Brown, Shuying Wang, Jeanne A. Stuckey, Xinquan Wang

published 06 Jan 2016

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Efficacy and Safety of Fingolimod in an Unselected Patient Population

Maria Rasenack, Jonathan Rychen, Michaela Andelova, Yvonne Naegelin, Christoph Stippich, Ludwig Kappos, Raija L. P. Lindberg, Till Sprenger, Tobias Derfuss

published 06 Jan 2016

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Antagonism of the Prokineticin System Prevents and Reverses Allodynia and Inflammation in a Mouse Model of Diabetes

Mara Castelli, Giada Amodeo, Lucia Negri, Roberta Lattanzi, Daniela Maftei, Cecilia Gotti, Francesco Pistillo, Valentina Onnis, Cenzo Congu, Alberto E. Panerai, Paola Sacerdote, Silvia Franchi

published 05 Jan 2016

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Cardiomyocyte Antihypertrophic Effect of Adipose Tissue Conditioned Medium from Rats and Its Abrogation by Obesity is Mediated by the Leptin to Adiponectin Ratio

Suresh C. Bairwa, Venkatesh Rajapurohitam, Xiaohong Tracey Gan, Rabban Mangat, Spencer D. Proctor, Morris Karmazyn

published 05 Jan 2016

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The agr Inhibitors Solonamide B and Analogues Alter Immune Responses to Staphylococccus aureus but Do Not Exhibit Adverse Effects on Immune Cell Functions

Mara Baldry, Betül Kitir, Hanne Frøkiær, Simon B. Christensen, Nico Taverne, Marjolein Meijerink, Henrik Franzyk, Christian A. Olsen, Jerry M. Wells, Hanne Ingmer

published 05 Jan 2016

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Ibuprofen Blunts Ventilatory Acclimatization to Sustained Hypoxia in Humans

Kemal Erdem Basaran, Michael Villongco, Baran Ho, Erika Ellis, Rachel Zarndt, Julie Antonova, Susan R. Hopkins, Frank L. Powell

published 04 Jan 2016

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