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Microglial cells

TNFAIP3 alleviates cerebral ischemia-reperfusion injury by inhibiting M1 microglia polarization via deubiquitination of RACK1

Wenya Bai, Shixuan Liu, Guilin Zhou, Xuelian Li, Huan Jiang, Jianlin Shao, Junchao Zhu

published 26 Nov 2025

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Mature tau pathology is not improved by interfering with interleukin-1 receptor signaling in two mouse models of tauopathy

Dylan J. Finneran, Brianna M. Jackman, Taylor Desjarlais, Alayna Henry, Ahlam S. Soliman, Patricia C. Muskus, Rama Shankar, Bin Chen, Kevin R. Nash, Dave Morgan, Marcia N. Gordon

published 05 Nov 2025

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TRIM37-mediated stabilization of PEX5 via monoubiquitination attenuates oxidative stress and demyelination in multiple sclerosis insights from EAE and LPC-induced experimental models

Lai Jiang, Yue Jin, Yujia Han, Jin Fu

published 24 Oct 2025

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Caveolin-1 knockout improves CFA-induced inflammatory pain in adult mice through modulating the cGAS STING pathway and autophagy

Huan Chang, Cancan Cheng, Ning Zheng, Haiyan Zhu, Hui Yang, Xiaocheng Zhu, Fan Zhang

published 09 Oct 2025

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Role of mTORC1 signaling in postnatal microglia activation preceding neurodegeneration in a mouse model for Niemann-Pick disease Type C

Caroline E. Murray, David S. Betancourt-Trompa, Michael S. Martinez, Julia M. Carson, Lindsay J. Walsh, Will C. Remillard, Kayla B. Fordyce, Rohan Reddy, Ileana Soto

published 05 Sep 2025

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Phosphatidylcholine suppresses inflammatory responses in LPS-stimulated MG6 microglial cells by inhibiting NF-κB/JNK/p38 MAPK signaling

Sachiko Mizuno, Yuki Kurobe-Takashima, Daisuke Kuriki, Kenta Susaki, Kurataka Otsuka, Tomoko Tsuchihashi, Keiko Abe, Shoko Kobayashi

published 28 Jul 2025

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Peripheral administration of blood from tau transgenic animals exacerbates brain tau-associated pathology

Laura Vegas-Gomez, Matias Pizarro, Jesus Garcia-Martin, Maria Angeles Arredondo-Alcala, Bianca Bustamante, Carolina Gonzalez-Silva, Soledad Matus, Rodrigo Diaz-Espinoza, Antonia Gutierrez, Rodrigo Morales, Claudia Duran-Aniotz, Ines Moreno-Gonzalez

published 15 Jul 2025

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IFN-γ signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice

Catherine M. Kerr, Macie A. Proctor-Roser, Srivatsan Parthasarathy, Joseph J. O’Connor, Jessica J. Pfannenstiel, Robin C. Orozco, Anthony R. Fehr

published 05 Jun 2025

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A graded neonatal mouse model of necrotizing enterocolitis demonstrates that mild enterocolitis is sufficient to activate microglia and increase cerebral cytokine expression

Cuilee Sha, Trevor Van Brunt, Jacob Kudria, Donna Schmidt, Alisa Yurovsky, Jela Bandovic, Michael Giarrizzo, Joyce Lin, Styliani-Anna Tsirka, Agnieszka B. Bialkowska, Lonnie P. Wollmuth, Esther M. Speer, Helen Hsieh

published 30 May 2025

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3-Deoxysappanchalcone attenuates LPS-induced neuroinflammation in microglia cell culture and ameliorates cognitive impairment in traumatic brain injury

Zemeng Li, Dangli Ren, Jingjing Wang, Yatao Wang, Yueyang Chen, Yunfeng Diao, Jianwei Li, Yang Qu, Maohua Zheng, Hongtao Sun

published 30 May 2025

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Findings from transcriptomics and immunohistochemistry indicate an autoimmune disease targeting brainstem inhibitory interneurons in bovine spastic paresis

Frederik Krull, Shahrbanou Hosseini, Martina Bleyer, Bertram Brenig

published 29 May 2025

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Hancinone possesses potentials on increasing the ability of HMC3 cells to phagocytosis of Aβ_1-42 via TREM2/Syk/PI3K/AKT/mTOR signaling pathway

Yushun Zhou, Guran Yu, Hao Li

published 27 May 2025

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Klotho null mutation leads to retinal degeneration characterized by functional impairment, gliosis, and deposition of amyloid-beta and hyperphosphorylated tau proteins

Zhi-Jia Chen, Chun-Yen Wu, Fang-Yan Hsiao, Jing-Chun Ma, Gabriel Lai, Han-Hsin Chang, David Pei-Cheng Lin

published 15 May 2025

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