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Microbicides

Glycerol Monolaurate Microbicide Protection against Repeat High-Dose SIV Vaginal Challenge

Ashley T. Haase, Eva Rakasz, Nancy Schultz-Darken, Karla Nephew, Kimberly L. Weisgrau, Cavan S. Reilly, Qingsheng Li, Peter J. Southern, Meghan Rothenberger, Marnie L. Peterson, Patrick M. Schlievert

published 09 Jun 2015

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Gene Expression Profiling of Human Vaginal Cells In Vitro Discriminates Compounds with Pro-Inflammatory and Mucosa-Altering Properties: Novel Biomarkers for Preclinical Testing of HIV Microbicide Candidates

Irina A. Zalenskaya, Theresa Joseph, Jasmin Bavarva, Nazita Yousefieh, Suzanne S. Jackson, Titilayo Fashemi, Hidemi S. Yamamoto, Robert Settlage, Raina N. Fichorova, Gustavo F. Doncel

published 08 Jun 2015

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A Temperature-Monitoring Vaginal Ring for Measuring Adherence

Peter Boyd, Delphine Desjardins, Sandeep Kumar, Susan M. Fetherston, Roger Le-Grand, Nathalie Dereuddre-Bosquet, Berglind Helgadóttir, Ásgeir Bjarnason, Manjula Narasimhan, R. Karl Malcolm

published 12 May 2015

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A Phase 1 Randomized, Open Label, Rectal Safety, Acceptability, Pharmacokinetic, and Pharmacodynamic Study of Three Formulations of Tenofovir 1% Gel (the CHARM-01 Study)

Ian Mcgowan, Ross D. Cranston, Kathryn Duffill, Aaron Siegel, Jarret C. Engstrom, Alexyi Nikiforov, Cindy Jacobson, Khaja K. Rehman, Julie Elliott, Elena Khanukhova, Kaleab Abebe, Christine Mauck, Hans M. L. Spiegel, Charlene S. Dezzutti, Lisa C. Rohan, Mark A. Marzinke, Hiwot Hiruy, Craig W. Hendrix, Nicola Richardson-Harman, Peter A. Anton

published 05 May 2015

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Facilitators of Adherence to the Study Pill in the FEM-PrEP Clinical Trial

Amy Corneli, Brian Perry, Kawango Agot, Khatija Ahmed, Fulufhelo Malamatsho, Lut Van Damme

published 13 Apr 2015

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MABGEL 1: First Phase 1 Trial of the Anti-HIV-1 Monoclonal Antibodies 2F5, 4E10 and 2G12 as a Vaginal Microbicide

Georgina C. Morris, Rebecca C. Wiggins, Sarah C. Woodhall, J. Martin Bland, Carol R. Taylor, Vicky Jespers, Brigitta A. Vcelar, Charles J. Lacey

published 29 Dec 2014

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Anti-HIV-1 Activity of Flavonoid Myricetin on HIV-1 Infection in a Dual-Chamber In Vitro Model

Silvana Pasetto, Vanessa Pardi, Ramiro Mendonça Murata

published 29 Dec 2014

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Development of a Composite Measure of Product Adherence, Protocol Compliance, and Semen Exposure Using DNA and Protein Biomarkers for Topical HIV Prevention Studies

Terry A. Jacot, Ashley Nelson, Andrea Thurman, Angela D. M. Kashuba, David F. Archer, Gustavo F. Doncel

published 09 Dec 2014

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Correlation between Compartmental Tenofovir Concentrations and an Ex Vivo Rectal Biopsy Model of Tissue Infectibility in the RMP-02/MTN-006 Phase 1 Study

Nicola Richardson-Harman, Craig W. Hendrix, Namandjé N. Bumpus, Christine Mauck, Ross D. Cranston, Kuo Yang, Julie Elliott, Karen Tanner, Ian McGowan, Angela Kashuba, Peter A. Anton

published 28 Oct 2014

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New Candidate Biomarkers in the Female Genital Tract to Evaluate Microbicide Toxicity

Scott Fields, Benben Song, Bareza Rasoul, Julie Fong, Melissa G. Works, Kenneth Shew, Ying Yiu, Jon Mirsalis, Annalisa D'Andrea

published 21 Oct 2014

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A MIV-150/Zinc Acetate Gel Inhibits SHIV-RT Infection in Macaque Vaginal Explants

Patrick Barnable, Giulia Calenda, Louise Ouattara, Agegnehu Gettie, James Blanchard, Ninochka Jean-Pierre, Larisa Kizima, Aixa Rodríguez, Ciby Abraham, Radhika Menon, Samantha Seidor, Michael L. Cooney, Kevin D. Roberts, Rhoda Sperling, Michael Piatak Jr, Jeffrey D. Lifson, Jose A. Fernandez-Romero, Thomas M. Zydowsky, Melissa Robbiani, Natalia Teleshova

published 26 Sep 2014

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Relationships between Perceptual Attributes and Rheology in Over-the-Counter Vaginal Products: A Potential Tool for Microbicide Development

Ellen D. Mahan, Toral Zaveri, Gregory R. Ziegler, John E. Hayes

published 04 Sep 2014

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HIV-1 Specific IgA Detected in Vaginal Secretions of HIV Uninfected Women Participating in a Microbicide Trial in Southern Africa Are Primarily Directed Toward gp120 and gp140 Specificities

Kelly E. Seaton, Lamar Ballweber, Audrey Lan, Michele Donathan, Sean Hughes, Lucia Vojtech, M. Anthony Moody, Hua-Xin Liao, Barton F. Haynes, Christine G. Galloway, Barbra A. Richardson, Salim Abdool Karim, Charlene S. Dezzutti, M. Juliana McElrath, Georgia D. Tomaras, Florian Hladik

published 23 Jul 2014

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