Advertisement

Browse Subject Areas

?

Click through the PLOS taxonomy to find articles in your field.

For more information about PLOS Subject Areas, click here.

Library screening

CDK4/6 inhibition synergizes with inhibition of P21-Activated Kinases (PAKs) in lung cancer cell lines

Gabriela M. Wright, Nick T. Gimbrone, Bhaswati Sarcar, Trent R. Percy, Edna R. Gordián, Fumi Kinose, Natália J. Sumi, Uwe Rix, W. Douglas Cress

published 17 Jun 2021

Loading metrics information...

Metrics unavailable. Please check back later.

Evaluation of Hsp90 and mTOR inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer

Evelyn M. Mrozek, Vineeta Bajaj, Yanan Guo, Izabela A. Malinowska, Jianming Zhang, David J. Kwiatkowski

published 23 Apr 2021

Loading metrics information...

Metrics unavailable. Please check back later.

4-(2,5-Dimethyl-1H-pyrrol-1-yl)-N-(2,5-dioxopyrrolidin-1-yl) benzamide improves monoclonal antibody production in a Chinese hamster ovary cell culture

Yuichi Aki, Yuta Katsumata, Hirofumi Kakihara, Koichi Nonaka, Kenshu Fujiwara

published 22 Apr 2021

Loading metrics information...

Metrics unavailable. Please check back later.

High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity

Ryan Choi, Mowei Zhou, Roger Shek, Jesse W. Wilson, Logan Tillery, Justin K. Craig, Indraneel A. Salukhe, Sarah E. Hickson, Neeraj Kumar, Rhema M. James, Garry W. Buchko, Ruilian Wu, Sydney Huff, Tu-Trinh Nguyen, Brett L. Hurst, Sara Cherry, Lynn K. Barrett, Jennifer L. Hyde, Wesley C. Van Voorhis

published 22 Apr 2021

Loading metrics information...

Metrics unavailable. Please check back later.

Selective killing of homologous recombination-deficient cancer cell lines by inhibitors of the RPA:RAD52 protein-protein interaction

Mona Al-Mugotir, Jeffrey J. Lovelace, Joseph George, Mika Bessho, Dhananjaya Pal, Lucas Struble, Carol Kolar, Sandeep Rana, Amarnath Natarajan, Tadayoshi Bessho, Gloria E. O. Borgstahl

published 30 Mar 2021

Loading metrics information...

Metrics unavailable. Please check back later.

Drug screening to identify compounds to act as co-therapies for the treatment of Burkholderia species

Sam Barker, Sarah V. Harding, David Gray, Mark I. Richards, Helen S. Atkins, Nicholas J. Harmer

published 25 Mar 2021

Loading metrics information...

Metrics unavailable. Please check back later.

A “ligand-targeting” peptide-drug conjugate: Targeted intracellular drug delivery by VEGF-binding helix-loop-helix peptides via receptor-mediated endocytosis

Masataka Michigami, Kentaro Takahashi, Haruna Yamashita, Zhengmao Ye, Ikuhiko Nakase, Ikuo Fujii

published 25 Feb 2021

Loading metrics information...

Metrics unavailable. Please check back later.

Mapping major SARS-CoV-2 drug targets and assessment of druggability using computational fragment screening: Identification of an allosteric small-molecule binding site on the Nsp13 helicase

Matthew R. Freidel, Roger S. Armen

published 17 Feb 2021

Loading metrics information...

Metrics unavailable. Please check back later.

Substitutional landscape of a split fluorescent protein fragment using high-density peptide microarrays

Oana N. Antonescu, Andreas Rasmussen, Nicole A. M. Damm, Ditte F. Heidemann, Roman Popov, Alexander Nesterov-Mueller, Kristoffer E. Johansson, Jakob R. Winther

published 03 Feb 2021

Loading metrics information...

Metrics unavailable. Please check back later.

A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV2 main protease

Jeremy D. Baker, Rikki L. Uhrich, Gerald C. Kraemer, Jason E. Love, Brian C. Kraemer

published 01 Feb 2021

Loading metrics information...

Metrics unavailable. Please check back later.

Identification of Prostaglandin F2 Receptor Negative Regulator (PTGFRN) as an internalizable target in cancer cells for antibody-drug conjugate development

Jorge Marquez, Jianping Dong, Chun Dong, Changsheng Tian, Ginette Serrero

published 27 Jan 2021

Loading metrics information...

Metrics unavailable. Please check back later.

Functional screening of a Caatinga goat (Capra hircus) rumen metagenomic library reveals a novel GH3 β-xylosidase

Betulia de Morais Souto, Ana Carolina Bitencourt de Araújo, Pedro Ricardo Vieira Hamann, Andrêssa de Rezende Bastos, Isabel de Souza Cunha, Julianna Peixoto, Ricardo Henrique Kruger, Eliane Ferreira Noronha, Betania Ferraz Quirino

published 15 Jan 2021

Loading metrics information...

Metrics unavailable. Please check back later.

Development of an orally-administrable tumor vasculature-targeting therapeutic using annexin A1-binding D-peptides

Motohiro Nonaka, Hideaki Mabashi-Asazuma, Donald L. Jarvis, Kazuhiko Yamasaki, Tomoya O. Akama, Masato Nagaoka, Toshio Sasai, Itsuko Kimura-Takagi, Yoichi Suwa, Takashi Yaegashi, Chun-Teng Huang, Chizuko Nishizawa-Harada, Michiko N. Fukuda

published 06 Jan 2021

Loading metrics information...

Metrics unavailable. Please check back later.

Advertisement

Create a weekly email alert for: Library screening

You can change these options by clicking profile then "Alerts and Notifications"