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Library screening

A Screen for Kinetochore-Microtubule Interaction Inhibitors Identifies Novel Antitubulin Compounds

Emanuela Screpanti, Stefano Santaguida, Tam Nguyen, Romano Silvestri, Rick Gussio, Andrea Musacchio, Ernest Hamel, Peter De Wulf

published 15 Jul 2010

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Protein-Protein Interaction Antagonists as Novel Inhibitors of Non-Canonical Polyubiquitylation

Johanna Scheper, Marta Guerra-Rebollo, Glòria Sanclimens, Alejandra Moure, Isabel Masip, Domingo González-Ruiz, Nuria Rubio, Bernat Crosas, Óscar Meca-Cortés, Noureddine Loukili, Vanessa Plans, Antonio Morreale, Jerónimo Blanco, Angel R. Ortiz, Àngel Messeguer, Timothy M. Thomson

published 30 Jun 2010

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Transmembrane and Ubiquitin-Like Domain Containing 1 (Tmub1) Regulates Locomotor Activity and Wakefulness in Mice and Interacts with CAMLG

Wandong Zhang, Katerina V. Savelieva, Adisak Suwanichkul, Daniel L. Small, Laura L. Kirkpatrick, Nianhua Xu, Thomas H. Lanthorn, Gui-Lan Ye

published 22 Jun 2010

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Discovery of High-Affinity Protein Binding Ligands – Backwards

Chris W. Diehnelt, Miti Shah, Nidhi Gupta, Paul E. Belcher, Matthew P. Greving, Phillip Stafford, Stephen Albert Johnston

published 19 May 2010

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Characterization of the Raf Kinase Inhibitory Protein (RKIP) Binding Pocket: NMR-Based Screening Identifies Small-Molecule Ligands

Anne N. Shemon, Gary L. Heil, Alexey E. Granovsky, Mathew M. Clark, Dan McElheny, Alexander Chimon, Marsha R. Rosner, Shohei Koide

published 05 May 2010

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Secreted Mycobacterium tuberculosis Rv3654c and Rv3655c Proteins Participate in the Suppression of Macrophage Apoptosis

Lia Danelishvili, Yoshitaka Yamazaki, Jeannie Selker, Luiz E. Bermudez

published 04 May 2010

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Binding-Site Assessment by Virtual Fragment Screening

Niu Huang, Matthew P. Jacobson

published 09 Apr 2010

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Discovery of Fragment Molecules That Bind the Human Peroxiredoxin 5 Active Site

Sarah Barelier, Dominique Linard, Julien Pons, André Clippe, Bernard Knoops, Jean-Marc Lancelin, Isabelle Krimm

published 17 Mar 2010

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Novel HIV-1 Knockdown Targets Identified by an Enriched Kinases/Phosphatases shRNA Library Using a Long-Term Iterative Screen in Jurkat T-Cells

Sylvie Rato, Sara Maia, Paula M. Brito, Leonor Resende, Carina F. Pereira, Catarina Moita, Rui P. Freitas, José Moniz-Pereira, Nir Hacohen, Luis Ferreira Moita, Joao Goncalves

published 17 Feb 2010

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Mutational Analysis of Highly Conserved Residues in the Phage PhiC31 Integrase Reveals Key Amino Acids Necessary for the DNA Recombination

Shaohui Liu, Jinfang Ma, Wei Wang, Maoxiang Zhang, Qingting Xin, Siman Peng, Rongxiu Li, Huanzhang Zhu

published 25 Jan 2010

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Discovery of Novel Proteasome Inhibitors Using a High-Content Cell-Based Screening System

Irena Lavelin, Avital Beer, Zvi Kam, Varda Rotter, Moshe Oren, Ami Navon, Benjamin Geiger

published 30 Dec 2009

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Efficient Assembly and Secretion of Recombinant Subviral Particles of the Four Dengue Serotypes Using Native prM and E Proteins

Pei-Gang Wang, Mateusz Kudelko, Joanne Lo, Lewis Yu Lam Siu, Kevin Tsz Hin Kwok, Martin Sachse, John M. Nicholls, Roberto Bruzzone, Ralf M. Altmeyer, Béatrice Nal

published 15 Dec 2009

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Generation and Characterization of Fmr1 Knockout Zebrafish

Marjo J. den Broeder, Herma van der Linde, Judith R. Brouwer, Ben A. Oostra, Rob Willemsen, René F. Ketting

published 19 Nov 2009

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