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Library screening

Deciphering the relational dynamics of AF-2 domain of PAN PPAR through drug repurposing and comparative simulations

Fouzia Gul, Nousheen Parvaiz, Syed Sikander Azam

published 31 Mar 2023

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Novel carbon skeletons activate human NicotinAMide Phosphoribosyl Transferase (NAMPT) enzyme in biochemical assay

Karen H. Almeida, Lisbeth Avalos-Irving, Steven Berardinelli, Kristen Chauvin, Silvia Yanez

published 30 Mar 2023

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Characterizing the consensus residue specificity and surface of BCL-2 binding to BH3 ligands using the Knob-Socket model

Jennifer Yi, Vivian Kellner, Hyun Joo, Nathaniel Chien, Shivarni Patel, Zaina Chaban, Jerry Tsai

published 16 Feb 2023

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Pandemic Response Box^® library as a source of antifungal drugs against Scedosporium and Lomentospora species

Rodrigo Rollin-Pinheiro, Mariana Ingrid Dutra da Silva Xisto, Yuri de Castro-Almeida, Victor Pereira Rochetti, Luana Pereira Borba-Santos, Yasmin da Silva Fontes, Antonio Ferreira-Pereira, Sonia Rozental, Eliana Barreto-Bergter

published 03 Feb 2023

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Repositioning of anti-dengue compounds against SARS-CoV-2 as viral polyprotein processing inhibitor

Leena H. Bajrai, Arwa A. Faizo, Areej A. Alkhaldy, Vivek Dhar Dwivedi, Esam I. Azhar

published 16 Nov 2022

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Identification of a novel CDK9 inhibitor targeting the intramolecular hidden cavity of CDK9 induced by Tat binding

Kaori Asamitsu, Takatsugu Hirokawa, Takashi Okamoto

published 15 Nov 2022

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Discovery of a novel natural product inhibitor of Clostridioides difficile with potent activity in vitro and in vivo

Rusha Pal, Mohamed N. Seleem

published 08 Aug 2022

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A bacterial dual positive and negative selection system for dCas9 activity

Shaun Spisak, Brett O’Brien, Marc Ostermeier

published 03 Jun 2022

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The use of a chimeric antigen for Plasmodium falciparum and P. vivax seroprevalence estimates from community surveys in Ethiopia and Costa Rica

Jessica N. McCaffery, Balwan Singh, Douglas Nace, Ashenafi Assefa, Jimee Hwang, Mateusz Plucinski, Nidia Calvo, Alberto Moreno, Venkatachalam Udhayakumar, Eric Rogier

published 25 May 2022

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Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex

Kepeng Che, Ajaybabu V. Pobbati, Caleb N. Seavey, Yuriy Fedorov, Anton A. Komar, Ashley Burtscher, Shuang Ma, Brian P. Rubin

published 13 Apr 2022

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Development of mAb-based polyglutamine-dependent and polyglutamine length-independent huntingtin quantification assays with cross-site validation

David F. Fischer, Sipke Dijkstra, Kimberly Lo, Johnny Suijker, Ana C. P. Correia, Patricia Naud, Martin Poirier, Michela A. Tessari, Ivette Boogaard, Geraldine Flynn, Mijke Visser, Marieke B. A. C. Lamers, George McAllister, Ignacio Munoz-Sanjuan, Douglas Macdonald

published 08 Apr 2022

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A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model

Dorjbal Dorjsuren, Richard T. Eastman, Min Jae Song, Adam Yasgar, Yuchi Chen, Kapil Bharti, Alexey V. Zakharov, Ajit Jadhav, Marc Ferrer, Pei-Yong Shi, Anton Simeonov

published 18 Jan 2022

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Evaluation of Xa inhibitors as potential inhibitors of the SARS-CoV-2 Mpro protease

Katarzyna Papaj, Patrycja Spychalska, Patryk Kapica, André Fischer, Jakub Nowak, Maria Bzówka, Manuel Sellner, Markus A. Lill, Martin Smieško, Artur Góra

published 11 Jan 2022

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