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Library screening

High-Affinity Inhibitors of Human NAD⁺-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships

Frank H. Niesen, Lena Schultz, Ajit Jadhav, Chitra Bhatia, Kunde Guo, David J. Maloney, Ewa S. Pilka, Minghua Wang, Udo Oppermann, Tom D. Heightman, Anton Simeonov

published 02 Nov 2010

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Novel HTS Strategy Identifies TRAIL-Sensitizing Compounds Acting Specifically Through the Caspase-8 Apoptotic Axis

Darren Finlay, Robyn D. Richardson, Lisa K. Landberg, Amy L. Howes, Kristiina Vuori

published 12 Oct 2010

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Identification of the Essential Brucella melitensis Porin Omp2b as a Suppressor of Bax-Induced Cell Death in Yeast in a Genome-Wide Screening

Géraldine Laloux, Michaël Deghelt, Marie de Barsy, Jean-Jacques Letesson, Xavier De Bolle

published 11 Oct 2010

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Functional Metagenomics: A High Throughput Screening Method to Decipher Microbiota-Driven NF-κB Modulation in the Human Gut

Omar Lakhdari, Antonietta Cultrone, Julien Tap, Karine Gloux, Françoise Bernard, S. Dusko Ehrlich, Fabrice Lefèvre, Joël Doré, Hervé M. Blottière

published 30 Sep 2010

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Identification of Novel p53 Pathway Activating Small-Molecule Compounds Reveals Unexpected Similarities with Known Therapeutic Agents

Karita Peltonen, Laureen Colis, Hester Liu, Sari Jäämaa, Henna M. Moore, Juulia Enbäck, Pirjo Laakkonen, Anne Vaahtokari, Richard J. Jones, Taija M. af Hällström, Marikki Laiho

published 27 Sep 2010

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A Multi-Parameter, High-Content, High-Throughput Screening Platform to Identify Natural Compounds that Modulate Insulin and Pdx1 Expression

Jessica A. Hill, Marta Szabat, Corinne A. Hoesli, Blair K. Gage, Yu Hsuan C. Yang, David E. Williams, Michael J. Riedel, Dan S. Luciani, Tatyana B. Kalynyak, Kevin Tsai, Ziliang Ao, Raymond J. Andersen, Garth L. Warnock, James M. Piret, Timothy J. Kieffer, James D. Johnson

published 23 Sep 2010

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Serum Stabilities of Short Tryptophan- and Arginine-Rich Antimicrobial Peptide Analogs

Leonard T. Nguyen, Johnny K. Chau, Nicole A. Perry, Leonie de Boer, Sebastian A. J. Zaat, Hans J. Vogel

published 10 Sep 2010

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Identifying Regulators for EAG1 Channels with a Novel Electrophysiology and Tryptophan Fluorescence Based Screen

Tinatin I. Brelidze, Anne E. Carlson, Douglas R. Davies, Lance J. Stewart, William N. Zagotta

published 02 Sep 2010

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Ctr2 Links Copper Homeostasis to Polysaccharide Capsule Formation and Phagocytosis Inhibition in the Human Fungal Pathogen Cryptococcus neoformans

Cheryl D. Chun, Hiten D. Madhani

published 02 Sep 2010

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Cheminformatics-Based Drug Design Approach for Identification of Inhibitors Targeting the Characteristic Residues of MMP-13 Hemopexin Domain

Roopa Kothapalli, Asif M. Khan, Basappa, Anupriya Gopalsamy, Yap Seng Chong, Loganath Annamalai

published 31 Aug 2010

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Identification of a Cardiac Specific Protein Transduction Domain by In Vivo Biopanning Using a M13 Phage Peptide Display Library in Mice

Maliha Zahid, Brett E. Phillips, Sean M. Albers, Nick Giannoukakis, Simon C. Watkins, Paul D. Robbins

published 17 Aug 2010

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Virtual Screening for HIV Protease Inhibitors: A Comparison of AutoDock 4 and Vina

Max W. Chang, Christian Ayeni, Sebastian Breuer, Bruce E. Torbett

published 04 Aug 2010

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High-Throughput Identification of Chemical Inhibitors of E. coli Group 2 Capsule Biogenesis as Anti-Virulence Agents

Carlos C. Goller, Patrick C. Seed

published 19 Jul 2010

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