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Library screening

Hydrogen Bonding Penalty upon Ligand Binding

Hongtao Zhao, Danzhi Huang

published 17 Jun 2011

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New Classes of Alanine Racemase Inhibitors Identified by High-Throughput Screening Show Antimicrobial Activity against Mycobacterium tuberculosis

Karen G. Anthony, Ulrich Strych, Kacheong R. Yeung, Carolyn S. Shoen, Oriana Perez, Kurt L. Krause, Michael H. Cynamon, Paul A. Aristoff, Raymond A. Koski

published 26 May 2011

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A Synthetic HIV-1 Subtype C Backbone Generates Comparable PR and RT Resistance Profiles to a Subtype B Backbone in a Recombinant Virus Assay

David Nauwelaers, Margriet Van Houtte, Bart Winters, Kim Steegen, Kurt Van Baelen, Ellen Chi, Mimi Zhou, Derek Steiner, Rachelle Bonesteel, Colin Aston, Lieven J. Stuyver

published 24 May 2011

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Systematic Exploitation of Multiple Receptor Conformations for Virtual Ligand Screening

Giovanni Bottegoni, Walter Rocchia, Manuel Rueda, Ruben Abagyan, Andrea Cavalli

published 17 May 2011

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A Novel Structural Framework for α_1A/D-Adrenoceptor Selective Antagonists Identified Using Subtype Selective Pharmacophores

Emily S. Stoddart, Sevvandi Senadheera, Iain J. A. MacDougall, Renate Griffith, Angela M. Finch

published 10 May 2011

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Antibody Engineering Using Phage Display with a Coiled-Coil Heterodimeric Fv Antibody Fragment

Xinwei Wang, Pinyu Zhong, Peter P. Luo, Kevin C. Wang

published 28 Apr 2011

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Single Cell Genome Amplification Accelerates Identification of the Apratoxin Biosynthetic Pathway from a Complex Microbial Assemblage

Rashel V. Grindberg, Thomas Ishoey, Dumitru Brinza, Eduardo Esquenazi, R. Cameron Coates, Wei-ting Liu, Lena Gerwick, Pieter C. Dorrestein, Pavel Pevzner, Roger Lasken, William H. Gerwick

published 12 Apr 2011

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RNAi-Based Screening Identifies Kinases Interfering with Dioxin-Mediated Up-Regulation of CYP1A1 Activity

David Gilot, Nolwenn Le Meur, Fanny Giudicelli, Marc Le Vée, Dominique Lagadic-Gossmann, Nathalie Théret, Olivier Fardel

published 29 Mar 2011

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A Tumor-Associated Mutation of FYVE-CENT Prevents Its Interaction with Beclin 1 and Interferes with Cytokinesis

Antonia P. Sagona, Ioannis P. Nezis, Kristi G. Bache, Kaisa Haglund, Anne Cathrine Bakken, Rolf I. Skotheim, Harald Stenmark

published 24 Mar 2011

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siRNA Screening of a Targeted Library of DNA Repair Factors in HIV Infection Reveals a Role for Base Excision Repair in HIV Integration

Amy S. Espeseth, Rick Fishel, Daria Hazuda, Qian Huang, Min Xu, Kristine Yoder, Honglin Zhou

published 23 Mar 2011

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FEZ2 Has Acquired Additional Protein Interaction Partners Relative to FEZ1: Functional and Evolutionary Implications

Marcos R. Alborghetti, Ariane S. Furlan, Jörg Kobarg

published 08 Mar 2011

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A High Throughput Screen Identifies Chemical Modulators of the Laminin-Induced Clustering of Dystroglycan and Aquaporin-4 in Primary Astrocytes

Geoffroy Noël, Sarah Stevenson, Hakima Moukhles

published 07 Mar 2011

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Antifungal Testing and High-Throughput Screening of Compound Library against Geomyces destructans, the Etiologic Agent of Geomycosis (WNS) in Bats

Sudha Chaturvedi, Sunanda S. Rajkumar, Xiaojiang Li, Gregory J. Hurteau, Michael Shtutman, Vishnu Chaturvedi

published 02 Mar 2011

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