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Library screening

Securinine, a Myeloid Differentiation Agent with Therapeutic Potential for AML

Kalpana Gupta, Amitabha Chakrabarti, [ ... ], David N. Wald

Hydrogen Bonding Penalty upon Ligand Binding

Hongtao Zhao, Danzhi Huang

New Classes of Alanine Racemase Inhibitors Identified by High-Throughput Screening Show Antimicrobial Activity against Mycobacterium tuberculosis

Karen G. Anthony, Ulrich Strych, [ ... ], Raymond A. Koski

A Synthetic HIV-1 Subtype C Backbone Generates Comparable PR and RT Resistance Profiles to a Subtype B Backbone in a Recombinant Virus Assay

David Nauwelaers, Margriet Van Houtte, [ ... ], Lieven J. Stuyver

Systematic Exploitation of Multiple Receptor Conformations for Virtual Ligand Screening

Giovanni Bottegoni, Walter Rocchia, [ ... ], Andrea Cavalli

A Novel Structural Framework for α_1A/D-Adrenoceptor Selective Antagonists Identified Using Subtype Selective Pharmacophores

Emily S. Stoddart, Sevvandi Senadheera, [ ... ], Angela M. Finch

Antibody Engineering Using Phage Display with a Coiled-Coil Heterodimeric Fv Antibody Fragment

Xinwei Wang, Pinyu Zhong, Peter P. Luo, Kevin C. Wang

Single Cell Genome Amplification Accelerates Identification of the Apratoxin Biosynthetic Pathway from a Complex Microbial Assemblage

Rashel V. Grindberg, Thomas Ishoey, [ ... ], William H. Gerwick

RNAi-Based Screening Identifies Kinases Interfering with Dioxin-Mediated Up-Regulation of CYP1A1 Activity

David Gilot, Nolwenn Le Meur, [ ... ], Olivier Fardel

A Tumor-Associated Mutation of FYVE-CENT Prevents Its Interaction with Beclin 1 and Interferes with Cytokinesis

Antonia P. Sagona, Ioannis P. Nezis, [ ... ], Harald Stenmark

siRNA Screening of a Targeted Library of DNA Repair Factors in HIV Infection Reveals a Role for Base Excision Repair in HIV Integration

Amy S. Espeseth, Rick Fishel, [ ... ], Honglin Zhou

FEZ2 Has Acquired Additional Protein Interaction Partners Relative to FEZ1: Functional and Evolutionary Implications

Marcos R. Alborghetti, Ariane S. Furlan, Jörg Kobarg

A High Throughput Screen Identifies Chemical Modulators of the Laminin-Induced Clustering of Dystroglycan and Aquaporin-4 in Primary Astrocytes

Geoffroy Noël, Sarah Stevenson, Hakima Moukhles

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