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Library screening

Highly Parallel Translation of DNA Sequences into Small Molecules

Rebecca M. Weisinger, S. Jarrett Wrenn, Pehr B. Harbury

The Role of the Parkinson's Disease Gene PARK9 in Essential Cellular Pathways and the Manganese Homeostasis Network in Yeast

Alessandra Chesi, Austin Kilaru, [ ... ], Aaron D. Gitler

Rationalization and Design of the Complementarity Determining Region Sequences in an Antibody-Antigen Recognition Interface

Chung-Ming Yu, Hung-Pin Peng, [ ... ], An-Suei Yang

A Chemical Analog of Curcumin as an Improved Inhibitor of Amyloid Abeta Oligomerization

Robert A. Orlando, Amanda M. Gonzales, [ ... ], David L. Vander Jagt

Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists

David Koes, Kareem Khoury, [ ... ], Carlos J. Camacho

Discovery of Inhibitors of Leishmania β-1,2-Mannosyltransferases Using a Click-Chemistry-Derived Guanosine Monophosphate Library

Phillip van der Peet, Julie E. Ralton, Malcolm J. McConville, Spencer J. Williams

Core Site-Moiety Maps Reveal Inhibitors and Binding Mechanisms of Orthologous Proteins by Screening Compound Libraries

Kai-Cheng Hsu, Wen-Chi Cheng, [ ... ], Jinn-Moon Yang

Identification of Mammalian Protein Quality Control Factors by High-Throughput Cellular Imaging

Gianluca Pegoraro, Ty C. Voss, [ ... ], Tom Misteli

Novel Protein Kinase Signaling Systems Regulating Lifespan Identified by Small Molecule Library Screening Using Drosophila

Stephen R. Spindler, Rui Li, [ ... ], Frank Sauer

Fingerprinting the Substrate Specificity of M1 and M17 Aminopeptidases of Human Malaria, Plasmodium falciparum

Marcin Poreba, Sheena McGowan, [ ... ], Marcin Drag

Kinome-Wide Functional Genomics Screen Reveals a Novel Mechanism of TNFα-Induced Nuclear Accumulation of the HIF-1α Transcription Factor in Cancer Cells

Angela Schoolmeesters, Daniel D. Brown, Yuriy Fedorov

Virtual Screening, Identification and In Vitro Testing of Novel Inhibitors of O-Acetyl-L-Serine Sulfhydrylase of Entamoeba histolytica

Isha Nagpal, Isha Raj, Naidu Subbarao, Samudrala Gourinath

Diversification of Specificity after Maturation of the Antibody Response to the HIV gp41 Epitope ELDKWA

Henry N. White, Qing-Hai Meng

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