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Library screening

Genetic Screening of New Genes Responsible for Cellular Adaptation to Hypoxia Using a Genome-Wide shRNA Library

Seiko Yoshino, Toshiro Hara, Jane S. Weng, Yuka Takahashi, Motoharu Seiki, Takeharu Sakamoto

published 16 Apr 2012

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Modulators of Prostate Cancer Cell Proliferation and Viability Identified by Short-Hairpin RNA Library Screening

Kimberly Brown Dahlman, Joel S. Parker, Tambudzai Shamu, Haley Hieronymus, Caren Chapinski, Brett Carver, Kenneth Chang, Gregory J. Hannon, Charles L. Sawyers

published 11 Apr 2012

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HIV-1 Phenotypic Reverse Transcriptase Inhibitor Drug Resistance Test Interpretation Is Not Dependent on the Subtype of the Virus Backbone

Michelle Bronze, Kim Steegen, Carole L. Wallis, Hans De Wolf, Maria A. Papathanasopoulos, Margriet Van Houtte, Wendy S. Stevens, Tobias Rinke de Wit, Lieven J. Stuyver, on behalf of the ART-A Consortium

published 09 Apr 2012

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Identification of Novel Mt-Guab2 Inhibitor Series Active against M. tuberculosis

Veeraraghavan Usha, Judith V. Hobrath, Sudagar S. Gurcha, Robert C. Reynolds, Gurdyal S. Besra

published 29 Mar 2012

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Highly Parallel Translation of DNA Sequences into Small Molecules

Rebecca M. Weisinger, S. Jarrett Wrenn, Pehr B. Harbury

published 29 Mar 2012

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The Role of the Parkinson's Disease Gene PARK9 in Essential Cellular Pathways and the Manganese Homeostasis Network in Yeast

Alessandra Chesi, Austin Kilaru, Xiaodong Fang, Antony A. Cooper, Aaron D. Gitler

published 23 Mar 2012

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Rationalization and Design of the Complementarity Determining Region Sequences in an Antibody-Antigen Recognition Interface

Chung-Ming Yu, Hung-Pin Peng, Ing-Chien Chen, Yu-Ching Lee, Jun-Bo Chen, Keng-Chang Tsai, Ching-Tai Chen, Jeng-Yih Chang, Ei-Wen Yang, Po-Chiang Hsu, Jhih-Wei Jian, Hung-Ju Hsu, Hung-Ju Chang, Wen-Lian Hsu, Kai-Fa Huang, Alex Che Ma, An-Suei Yang

published 22 Mar 2012

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A Chemical Analog of Curcumin as an Improved Inhibitor of Amyloid Abeta Oligomerization

Robert A. Orlando, Amanda M. Gonzales, Robert E. Royer, Lorraine M. Deck, David L. Vander Jagt

published 19 Mar 2012

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Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists

David Koes, Kareem Khoury, Yijun Huang, Wei Wang, Michal Bista, Grzegorz M. Popowicz, Siglinde Wolf, Tad A. Holak, Alexander Dömling, Carlos J. Camacho

published 12 Mar 2012

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Discovery of Inhibitors of Leishmania β-1,2-Mannosyltransferases Using a Click-Chemistry-Derived Guanosine Monophosphate Library

Phillip van der Peet, Julie E. Ralton, Malcolm J. McConville, Spencer J. Williams

published 29 Feb 2012

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Core Site-Moiety Maps Reveal Inhibitors and Binding Mechanisms of Orthologous Proteins by Screening Compound Libraries

Kai-Cheng Hsu, Wen-Chi Cheng, Yen-Fu Chen, Hung-Jung Wang, Ling-Ting Li, Wen-Ching Wang, Jinn-Moon Yang

published 29 Feb 2012

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Identification of Mammalian Protein Quality Control Factors by High-Throughput Cellular Imaging

Gianluca Pegoraro, Ty C. Voss, Scott E. Martin, Pinar Tuzmen, Rajarshi Guha, Tom Misteli

published 20 Feb 2012

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Novel Protein Kinase Signaling Systems Regulating Lifespan Identified by Small Molecule Library Screening Using Drosophila

Stephen R. Spindler, Rui Li, Joseph M. Dhahbi, Amy Yamakawa, Frank Sauer

published 20 Feb 2012

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