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Library screening

High-throughput screening identifies cell cycle-associated signaling cascades that regulate a multienzyme glucosome assembly in human cells

Danielle L. Schmitt, Patricia Dranchak, Prakash Parajuli, Dvir Blivis, Ty Voss, Casey L. Kohnhorst, Minjoung Kyoung, James Inglese, Songon An

published 04 Aug 2023

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Development and application of a qPCR-based genotyping assay for Ophidiomyces ophidiicola to investigate the epidemiology of ophidiomycosis

Ellen Haynes, Jeffrey Lorch, Matthew C. Allender

published 03 Aug 2023

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SUNi mutagenesis: Scalable and uniform nicking for efficient generation of variant libraries

Taylor L. Mighell, Ignasi Toledano, Ben Lehner

published 07 Jul 2023

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In-vitro high-throughput library screening—Kinetics and molecular docking studies of potent inhibitors of α-glucosidase

Majid Ali, Khuram Malik, Asma Zaidi, Umar Farooq, Syed Majid Bukhari, Zahid Majeed, Mater H. Mahnashi, Shamyla Nawazish, Alqahtani Abdulwahab, Khaled S. Alshaibari

published 30 Jun 2023

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High-throughput phenotypic screen identifies a new family of potent anti-amoebic compounds

Conall Sauvey, Ittipat Meewan, Gretchen Ehrenkaufer, Jonathan Blevitt, Paul Jackson, Ruben Abagyan

published 09 May 2023

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In silico elucidation of potential drug targets against oxygenase domain of Human eNOS Dysfunction

Abbeha Malik, Muhammad Nasir Iqbal, Sidrah Ashraf, Muhammad Saleem Khan, Samar Shahzadi, Muhammad Farhan Shafique, Zureesha Sajid, Muhammad Sajid, Sheikh Arslan Sehgal

published 26 Apr 2023

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Tannic acid, an IL-1β-direct binding compound, ameliorates IL-1β-induced inflammation and cartilage degradation by hindering IL-1β-IL-1R1 interaction

Hae-Ri Lee, Young-Jin Jeong, Joong-Woon Lee, JooYeon Jhun, Hyun Sik Na, Keun-Hyung Cho, Seok Jung Kim, Mi-La Cho, Tae-Hwe Heo

published 20 Apr 2023

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Optimised protocol for monitoring SARS-CoV-2 in wastewater using reverse complement PCR-based whole-genome sequencing

Harry T. Child, Paul A. O’Neill, Karen Moore, William Rowe, Hubert Denise, David Bass, Matthew J. Wade, Matt Loose, Steve Paterson, Ronny van Aerle, Aaron R. Jeffries

published 14 Apr 2023

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Deciphering the relational dynamics of AF-2 domain of PAN PPAR through drug repurposing and comparative simulations

Fouzia Gul, Nousheen Parvaiz, Syed Sikander Azam

published 31 Mar 2023

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Novel carbon skeletons activate human NicotinAMide Phosphoribosyl Transferase (NAMPT) enzyme in biochemical assay

Karen H. Almeida, Lisbeth Avalos-Irving, Steven Berardinelli, Kristen Chauvin, Silvia Yanez

published 30 Mar 2023

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Characterizing the consensus residue specificity and surface of BCL-2 binding to BH3 ligands using the Knob-Socket model

Jennifer Yi, Vivian Kellner, Hyun Joo, Nathaniel Chien, Shivarni Patel, Zaina Chaban, Jerry Tsai

published 16 Feb 2023

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Pandemic Response Box^® library as a source of antifungal drugs against Scedosporium and Lomentospora species

Rodrigo Rollin-Pinheiro, Mariana Ingrid Dutra da Silva Xisto, Yuri de Castro-Almeida, Victor Pereira Rochetti, Luana Pereira Borba-Santos, Yasmin da Silva Fontes, Antonio Ferreira-Pereira, Sonia Rozental, Eliana Barreto-Bergter

published 03 Feb 2023

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Repositioning of anti-dengue compounds against SARS-CoV-2 as viral polyprotein processing inhibitor

Leena H. Bajrai, Arwa A. Faizo, Areej A. Alkhaldy, Vivek Dhar Dwivedi, Esam I. Azhar

published 16 Nov 2022

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