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Library screening

Xenopus: An alternative model system for identifying muco-active agents

Hyo Jung Sim, Sang-Hyun Kim, Kyung-Jae Myung, Taejoon Kwon, Hyun-Shik Lee, Tae Joo Park

published 22 Feb 2018

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A generic HTS assay for kinase screening: Validation for the isolation of an engineered malate kinase

Romain Irague, Christopher M. Topham, Nelly Martineau, Audrey Baylac, Clément Auriol, Thomas Walther, Jean-Marie François, Isabelle André, Magali Remaud-Siméon

published 20 Feb 2018

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Conservation and lineage-specific rearrangements in the GOBP/PBP gene complex of distantly related ditrysian Lepidoptera

Yuji Yasukochi, Bin Yang, Toshiaki Fujimoto, Ken Sahara, Takashi Matsuo, Yukio Ishikawa

published 09 Feb 2018

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Target discovery screens using pooled shRNA libraries and next-generation sequencing: A model workflow and analytical algorithm

Christiane Schaefer, Nikhil Mallela, Jochen Seggewiß, Birgit Lechtape, Heymut Omran, Uta Dirksen, Eberhard Korsching, Jenny Potratz

published 31 Jan 2018

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An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells

Katharina Schrade, Jessica Tröger, Adeeb Eldahshan, Kerstin Zühlke, Kamal R. Abdul Azeez, Jonathan M. Elkins, Martin Neuenschwander, Andreas Oder, Mohamed Elkewedi, Sarah Jaksch, Karsten Andrae, Jinliang Li, Joao Fernandes, Paul Markus Müller, Stephan Grunwald, Stephen F. Marino, Tanja Vukićević, Jenny Eichhorst, Burkhard Wiesner, Marcus Weber, Michael Kapiloff, Oliver Rocks, Oliver Daumke, Thomas Wieland, Stefan Knapp, Jens Peter von Kries, Enno Klussmann

published 26 Jan 2018

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A pharmacological screen for compounds that rescue the developmental lethality of a Drosophila ATM mutant

Stacey A. Rimkus, David A. Wassarman

published 16 Jan 2018

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Application of a phenotypic drug discovery strategy to identify biological and chemical starting points for inhibition of TSLP production in lung epithelial cells

Adelina Orellana, Vicente García-González, Rosa López, Sonia Pascual-Guiral, Estrella Lozoya, Julia Díaz, Daniel Casals, Antolín Barrena, Stephane Paris, Miriam Andrés, Victor Segarra, Dolors Vilella, Rajneesh Malhotra, Paul Eastwood, Anna Planagumà, Montserrat Miralpeix, Arsenio Nueda

published 10 Jan 2018

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Isolation and characterization of a novel metagenomic enzyme capable of degrading bacterial phytotoxin toxoflavin

Ji-Eun Choi, Cuong Mai Nguyen, Boyoung Lee, Ji Hyun Park, Joon Young Oh, Jung Sup Choi, Jin-Cheol Kim, Jae Kwang Song

published 02 Jan 2018

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Using thermal scanning assays to test protein-protein interactions of inner-ear cadherins

Deepanshu Choudhary, Anusha Kumar, Thomas J. Magliery, Marcos Sotomayor

published 19 Dec 2017

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Discovery of carbamate degrading enzymes by functional metagenomics

Lisa Ufarté, Elisabeth Laville, Sophie Duquesne, Diego Morgavi, Patrick Robe, Christophe Klopp, Angeline Rizzo, Sandra Pizzut-Serin, Gabrielle Potocki-Veronese

published 14 Dec 2017

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Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity

Michael Wormald, Gangling Liao, Martha Kimos, James Barrow, Huijun Wei

published 29 Nov 2017

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RNAi screen reveals a role of SPHK2 in dengue virus–mediated apoptosis in hepatic cell lines

Atthapan Morchang, Regina Ching Hua Lee, Pa-thai Yenchitsomanus, Gopinathan Pillai Sreekanth, Sansanee Noisakran, Justin Jang Hann Chu, Thawornchai Limjindaporn

published 16 Nov 2017

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A composite docking approach for the identification and characterization of ectosteric inhibitors of cathepsin K

Simon Law, Preety Panwar, Jody Li, Adeleke H. Aguda, Andrew Jamroz, Rafael V. C. Guido, Dieter Brömme

published 31 Oct 2017

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