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Library screening

Enhanced ADCC Activity of Affinity Maturated and Fc-Engineered Mini-Antibodies Directed against the AML Stem Cell Antigen CD96

Sahar Mohseni Nodehi, Roland Repp, [ ... ], Andreas Humpe

Screening for Novel LRRK2 Inhibitors Using a High-Throughput TR-FRET Cellular Assay for LRRK2 Ser935 Phosphorylation

Spencer B. Hermanson, Coby B. Carlson, [ ... ], Kun Bi

Statins Decrease Lung Inflammation in Mice by Upregulating Tetraspanin CD9 in Macrophages

Yingji Jin, Isao Tachibana, [ ... ], Atsushi Kumanogoh

Screening Compounds with a Novel High-Throughput ABCB1-Mediated Efflux Assay Identifies Drugs with Known Therapeutic Targets at Risk for Multidrug Resistance Interference

Megan R. Ansbro, Suneet Shukla, [ ... ], Luowei Li

Using thermal scanning assays to test protein-protein interactions of inner-ear cadherins

Deepanshu Choudhary, Anusha Kumar, Thomas J. Magliery, Marcos Sotomayor

Global Analysis Reveals Families of Chemical Motifs Enriched for hERG Inhibitors

Fang Du, Joseph J. Babcock, [ ... ], Min Li

Discovery of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B (PtpB) Inhibitors from Natural Products

Alessandra Mascarello, Mattia Mori, [ ... ], Maurizio Botta

Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool

Katherine F. Donovan, Mudra Hegde, [ ... ], John G. Doench

A Universal Mariner Transposon System for Forward Genetic Studies in the Genus Clostridium

Ying Zhang, Alexander Grosse-Honebrink, Nigel P. Minton

An Intermittent Live Cell Imaging Screen for siRNA Enhancers and Suppressors of a Kinesin-5 Inhibitor

Melody Tsui, Tiao Xie, [ ... ], Timothy J. Mitchison

Functional Metagenomics Unveils a Multifunctional Glycosyl Hydrolase from the Family 43 Catalysing the Breakdown of Plant Polymers in the Calf Rumen

Manuel Ferrer, Azam Ghazi, [ ... ], Peter N. Golyshin

A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein

Joseph Carver, Thomas S. Dexheimer, [ ... ], Ji Luo

Antibody Engineering Using Phage Display with a Coiled-Coil Heterodimeric Fv Antibody Fragment

Xinwei Wang, Pinyu Zhong, Peter P. Luo, Kevin C. Wang

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