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Leukemia

Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins

Saran Feng, Jiannong Cen, Yihong Huang, Hongjie Shen, Li Yao, Yuanyuan Wang, Zixing Chen

published 17 Aug 2011

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Overexpression of Ubiquitin Specific Protease 44 (USP44) Induces Chromosomal Instability and Is Frequently Observed in Human T-Cell Leukemia

Ying Zhang, Jan van Deursen, Paul J. Galardy

published 11 Aug 2011

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Pronounced Hypoxia in Models of Murine and Human Leukemia: High Efficacy of Hypoxia-Activated Prodrug PR-104

Juliana Benito, Yuexi Shi, Barbara Szymanska, Hernan Carol, Ingrid Boehm, Hongbo Lu, Sergej Konoplev, Wendy Fang, Patrick A. Zweidler-McKay, Dario Campana, Gautam Borthakur, Carlos Bueso-Ramos, Elizabeth Shpall, Deborah A. Thomas, Craig T. Jordan, Hagop Kantarjian, William R. Wilson, Richard Lock, Michael Andreeff, Marina Konopleva

published 11 Aug 2011

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Single Molecule Analysis of c-myb Alternative Splicing Reveals Novel Classifiers for Precursor B-ALL

Ye E. Zhou, John P. O'Rourke, Jeremy S. Edwards, Scott A. Ness

published 11 Aug 2011

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Octa-Arginine Mediated Delivery of Wild-Type Lnk Protein Inhibits TPO-Induced M-MOK Megakaryoblastic Leukemic Cell Growth by Promoting Apoptosis

Chung Yeng Looi, Miki Imanishi, Satoshi Takaki, Miki Sato, Natsuko Chiba, Yoji Sasahara, Shiroh Futaki, Shigeru Tsuchiya, Satoru Kumaki

published 10 Aug 2011

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Synergistic Interactions between HDAC and Sirtuin Inhibitors in Human Leukemia Cells

Michele Cea, Debora Soncini, Floriana Fruscione, Lizzia Raffaghello, Anna Garuti, Laura Emionite, Eva Moran, Mirko Magnone, Gabriele Zoppoli, Daniele Reverberi, Irene Caffa, Annalisa Salis, Antonia Cagnetta, Micaela Bergamaschi, Salvatore Casciaro, Ivana Pierri, Gianluca Damonte, Filippo Ansaldi, Marco Gobbi, Vito Pistoia, Alberto Ballestrero, Franco Patrone, Santina Bruzzone, Alessio Nencioni

published 27 Jul 2011

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IRF4 Is a Suppressor of c-Myc Induced B Cell Leukemia

Simanta Pathak, Shibin Ma, Long Trinh, James Eudy, Kay-Uwe Wagner, Shantaram S. Joshi, Runqing Lu

published 27 Jul 2011

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Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice

Malini Mukherjee, Gouqing Ge, Nenggang Zhang, Eryong Huang, Lanelle V. Nakamura, Marissa Minor, Viacheslav Fofanov, Pullivarthi H. Rao, Alan Herron, Debananda Pati

published 25 Jul 2011

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Effects of Stem Cell Factor on Hypoxia-Inducible Factor 1 Alpha Accumulation in Human Acute Myeloid Leukaemia and LAD2 Mast Cells

Bernhard F. Gibbs, Inna M. Yasinska, Abraham E. Oniku, Vadim V. Sumbayev

published 20 Jul 2011

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Sulindac Sulfide Reverses Aberrant Self-Renewal of Progenitor Cells Induced by the AML-Associated Fusion Proteins PML/RARα and PLZF/RARα

Gunnar Steinert, Claudia Oancea, Jessica Roos, Heike Hagemeyer, Thorsten Maier, Martin Ruthardt, Elena Puccetti

published 19 Jul 2011

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Exploiting Mitochondrial Dysfunction for Effective Elimination of Imatinib-Resistant Leukemic Cells

Jérome Kluza, Manel Jendoubi, Caroline Ballot, Abir Dammak, Aurélie Jonneaux, Thierry Idziorek, Sami Joha, Véronique Dauphin, Myriam Malet-Martino, Stéphane Balayssac, Patrice Maboudou, Gilbert Briand, Pierre Formstecher, Bruno Quesnel, Philippe Marchetti

published 18 Jul 2011

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Securinine, a Myeloid Differentiation Agent with Therapeutic Potential for AML

Kalpana Gupta, Amitabha Chakrabarti, Sonia Rana, Ritu Ramdeo, Bryan L. Roth, Munna L. Agarwal, William Tse, Mukesh K. Agarwal, David N. Wald

published 24 Jun 2011

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Therapeutic Potential and Challenges of Targeting Receptor Tyrosine Kinase ROR1 with Monoclonal Antibodies in B-Cell Malignancies

Jiahui Yang, Sivasubramanian Baskar, Ka Yin Kwong, Michael G. Kennedy, Adrian Wiestner, Christoph Rader

published 15 Jun 2011

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