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Leukemia

Enzymatic properties of a L-asparaginase without secondary glutaminase activity from Streptomyces scabrisporus

Ricardo Rodríguez-Vargas, Francisca Villanueva-Flores, María Fernanda Gutiérrez-Chávez, Carlos Medrano-Villagómez, Andrés Zárate-Romero, Alejandro Huerta-Saquero

published 07 Nov 2025

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In-Silico discovery of Pediatric Acute-Myeloid-Leukemia (pAML) causing druggable molecular signatures highlighting their pathogenetic processes and therapeutic agents through single-cell RNA-Seq profile analysis

Md. Foysal Ahmed, Md. Al Noman, Md. Feroj Ahmed, Md. Abdul Latif, Md. Al Amin Pappu, Md. Shariful Islam, Md. Sanoar Hossain, Md. Bayazid Hossen, Md. Fahim Faysal, Md. Mehedi Hasan, Md. Nurul Haque Mollah

published 31 Oct 2025

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Association between obesity and mortality from hematological malignancies among Japanese adults: The Japan Collaborative Cohort study

Hana Wakasa, Satoshi Sunohara, Takashi Kimura, Takaya Ichikawa, Akiko Tamakoshi

published 30 Oct 2025

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Germinal center trajectories and transcriptional signatures define CLL subtypes and their pathway regulators

Ahmed Mohamed, Luca Giudice, José Basílio, Sabina Barresi, Pradeep Kumar Kopparapu, Vanda Friman, Marco Tartaglia, Tarja Malm, Andreas Tilevik, Ola Grimsholm

published 22 Oct 2025

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Comparison the impact of IFN-β alone or in combination with vitamin D on critical pathways involved in AML progression

Farzad Nasri, Hassan Jalaeikhoo, Maryam Dadmanesh, Nafiseh Behranvand, Reza Falak, Negin Hosseini Rouzbahan, Yalda Babaei, Khodayar Ghorban

published 16 Oct 2025

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HLF gene is a poor prognostic factor in acute myeloid leukemia patients with FLT3-ITD/NPM1 mutations undergoing hematopoietic transplantation

Xiaoyu Xu, Xinxin Ge, Airui Jiang, Jia Chen, Qiaocheng Qiu, Zixuan Ding, Mingqing Zhu, Jinlan Pan, Zixing Chen, Wenwen Du, Depei Wu, Suning Chen, Hongjie Shen

published 14 Oct 2025

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Structure-guided discovery and characterization of novel FLT3 inhibitors for acute myeloid leukemia treatment

Bishal Budha, Gourab Basu Choudhury, Md. Shohag Hossain, Arjun Acharya

published 13 Oct 2025

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Detection of leukemia gene fusions on DNA-level through targeted Next-Generation Sequencing

Bin Chen, Zhihui Gao, Long Chen, Hong Zhang, Yani Lin, Jing Li

published 09 Oct 2025

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Establishing disease-specific thresholds for automated hematopoietic progenitor cell counting in hematological malignancies

Orathai Taka, Anchalee Thedsawad, Weerapat Owattanapanich

published 08 Oct 2025

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Integrated analysis of ARHGAP6 potential function and prognostic value in acute myeloid leukemia

Debin Yang, Yuanzhe Li, Ping Ma, Fankai Xiao

published 07 Oct 2025

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Genomic discovery of EF-24 targets unveils antitumorigenic mechanisms in leukemia cells

Ajeet P. Singh, Noah Wax, James Duncan, Ana S. Fernandes, Jonathan L. Jacobs

published 23 Sep 2025

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Low survival in younger adults with Acute Myeloid Leukemia (AML) in Tanzania linked to high disease burden and socioeconomic factors

Michelle Munroe, Clara Chamba, Mbonea Yonazi, Samira Mahfudh, William Mawalla, Kelvin Mbelekwa, Gladys Kaaya, Rebbecca Mwakichako, Johnson Mshiu, Magdalena Lyimo, Mwashungi Ally, Ahlam Nasser

published 19 Sep 2025

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TRIM6 affects the prognosis of acute myeloid leukemia through the PI3K/AKT signaling pathway and is associated with immune infiltration

Jingxin Zhang, Wu Zhou, Yuancheng Liu, Chenglong Hu, Siqi Wang, Jianxia Xu, Sixi Wei

published 17 Sep 2025

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