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Ion channel gating

Catecholaminergic polymorphic ventricular tachycardia patients with multiple genetic variants in the PACES CPVT Registry

Thomas M. Roston, Omid Haji-Ghassemi, [ ... ], Shubhayan Sanatani

Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography

Nate Yoder, Eric Gouaux

How does binding of agonist ligands control intrinsic molecular dynamics in human NMDA receptors?

Zoltan Palmai, Kimberley Houenoussi, Sylvia Cohen-Kaminsky, Luba Tchertanov

TRESK background potassium channel is not gated at the helix bundle crossing near the cytoplasmic end of the pore

Miklós Lengyel, Gábor Czirják, Péter Enyedi

Contribution of S4 segments and S4-S5 linkers to the low-voltage activation properties of T-type Ca_V3.3 channels

Ana Laura Sanchez-Sandoval, Zazil Herrera Carrillo, [ ... ], Juan Carlos Gomora

Allosteric-activation mechanism of BK channel gating ring triggered by calcium ions

Ronghua Guan, Hui Zhou, [ ... ], Hailong An

Depolarization of the conductance-voltage relationship in the Na_V1.5 mutant, E1784K, is due to altered fast inactivation

Colin H. Peters, Alec Yu, [ ... ], Peter C. Ruben

Pulling MscL open via N-terminal and TM1 helices: A computational study towards engineering an MscL nanovalve

Adam D. Martinac, Navid Bavi, Omid Bavi, Boris Martinac

Permeation Mechanisms in the TMEM16B Calcium-Activated Chloride Channels

Simone Pifferi

Hyperthermia Influences the Effects of Sodium Channel Blocking Drugs in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Ibrahim El-Battrawy, Siegfried Lang, [ ... ], Xiao-Bo Zhou

Single Channel Recordings Reveal Differential β2 Subunit Modulations Between Mammalian and Drosophila BK_Ca(β2) Channels

Zhenzhen Yan, Bin Hu, [ ... ], Panpan Hou

Deleterious Rare Variants Reveal Risk for Loss of GABA_A Receptor Function in Patients with Genetic Epilepsy and in the General Population

Ciria C. Hernandez, Tara L. Klassen, [ ... ], Robert L. Macdonald

Ligand Binding at the α4-α4 Agonist-Binding Site of the α4β2 nAChR Triggers Receptor Activation through a Pre-Activated Conformational State

Dinesh C. Indurthi, Trevor M. Lewis, [ ... ], Nathan L. Absalom

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