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Insulin secretion

Significant expansion of the donor pool achieved by utilizing islets of variable quality in the production of allogeneic “Neo-Islets”, 3-D organoids of Mesenchymal Stromal and islet cells, a novel immune-isolating biotherapy for Type I Diabetes

Anna M. Gooch, Sabiha S. Chowdhury, Ping M. Zhang, Zhuma M. Hu, Christof Westenfelder

published 24 Aug 2023

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Quantifying postprandial glucose responses using a hybrid modeling approach: Combining mechanistic and data-driven models in The Maastricht Study

Balázs Erdős, Bart van Sloun, Gijs H. Goossens, Shauna D. O’Donovan, Bastiaan E. de Galan, Marleen M. J. van Greevenbroek, Coen D. A. Stehouwer, Miranda T. Schram, Ellen E. Blaak, Michiel E. Adriaens, Natal A. W. van Riel, Ilja C. W. Arts

published 27 Jul 2023

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DYRK1A inhibitors leucettines and TGF-β inhibitor additively stimulate insulin production in beta cells, organoids, and isolated mouse islets

Barbara Pucelik, Agata Barzowska, Anna Czarna

published 17 May 2023

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RyR2 regulates store-operated Ca²⁺ entry, phospholipase C activity, and electrical excitability in the insulinoma cell line INS-1

Kyle E. Harvey, Shiqi Tang, Emily K. LaVigne, Evan P. S. Pratt, Gregory H. Hockerman

published 04 May 2023

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Parkin-mediated mitophagy is negatively regulated by FOXO3A, which inhibits Plk3-mediated mitochondrial ROS generation in STZ diabetic stress-treated pancreatic β cells

Ji Yeon Shim, Jin Ook Chung, Dawa Jung, Pil Soo Kang, Seon-Young Park, Ayse Tuba Kendi, Val J. Lowe, SeungBaek Lee

published 03 May 2023

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Exploring the relationship between pancreatic fat and insulin secretion in overweight or obese women without type 2 diabetes mellitus: A preliminary investigation of the TOFI_Asia cohort

Ivana R. Sequeira, Wilson Yip, Louise W. Lu, Yannan Jiang, Rinki Murphy, Lindsay D. Plank, Garth J. S. Cooper, Carl N. Peters, Benjamin S. Aribsala, Kieren G. Hollingsworth, Sally D. Poppitt

published 30 Dec 2022

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A novel model of gestational diabetes: Acute high fat high sugar diet results in insulin resistance and beta cell dysfunction during pregnancy in mice

Akansha Mishra, Simone Hernandez Ruano, Pradip K. Saha, Kathleen A. Pennington

published 15 Dec 2022

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An intensity-based post-processing tool for 3D instance segmentation of organelles in soft X-ray tomograms

Angdi Li, Shuning Zhang, Valentina Loconte, Yan Liu, Axel Ekman, Garth J. Thompson, Andrej Sali, Raymond C. Stevens, Kate White, Jitin Singla, Liping Sun

published 01 Sep 2022

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Establishment of an enzyme-linked immunosorbent assay for mouse pancreatic polypeptide clarifies the regulatory mechanism of its secretion from pancreatic γ cells

Daisuke Saito, Yuko Nakagawa, Takashi Sato, Ayako Fukunaka, Ofejiro Blessing Pereye, Nobuhiro Maruyama, Hirotaka Watada, Yoshio Fujitani

published 17 Aug 2022

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Increase in glycemic set point, alongside a decrease in waist circumference, in the non-diabetic population during the Japanese National Intervention Program for metabolic syndrome: A single-center, large-scale, matched-pair analysis

Takuya Sugiyama, Yuya Yamada, Yoshito Ito, Ryohei Mineo, Ryuya Iwamoto, Sachiko Tamba, Takashi Fujimoto, Koji Yamamoto, Yuji Matsuzawa

published 10 Aug 2022

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Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia

Rashmi Chandra, Dipendra K. Aryal, Jonathan D. Douros, Rafiq Shahid, Supriya J. Davis, Jonathan E. Campbell, Olga Ilkayeya, Phillip J. White, Ramona Rodriguez, Christopher B. Newgard, William C. Wetsel, Rodger A. Liddle

published 24 Jun 2022

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Metabolic changes in vitamin D receptor knockout mice

Sue Lynn Lau, Rebecca A. Stokes, Beverly Ng, Kim Cheng, Roderick Clifton-Bligh, Jenny E. Gunton

published 17 Jun 2022

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A novel strategy for production of liraglutide precursor peptide and development of a new long-acting incretin mimic

Samaneh Ahmadi, Mohammad Bagher Shahsavani, Zohreh Tavaf, Rawayh Muslim Albaghlany, Ashutosh Kumar, Ali Akbar Moosavi-Movahedi, Reza Yousefi

published 02 May 2022

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