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Insulin secretion

Testing a new platform to screen disease-modifying therapy in type 1 diabetes

Sandra M. Lord, Henry T. Bahnson, [ ... ], Cate Speake

Significant expansion of the donor pool achieved by utilizing islets of variable quality in the production of allogeneic “Neo-Islets”, 3-D organoids of Mesenchymal Stromal and islet cells, a novel immune-isolating biotherapy for Type I Diabetes

Anna M. Gooch, Sabiha S. Chowdhury, [ ... ], Christof Westenfelder

Quantifying postprandial glucose responses using a hybrid modeling approach: Combining mechanistic and data-driven models in The Maastricht Study

Balázs Erdős, Bart van Sloun, [ ... ], Ilja C. W. Arts

DYRK1A inhibitors leucettines and TGF-β inhibitor additively stimulate insulin production in beta cells, organoids, and isolated mouse islets

Barbara Pucelik, Agata Barzowska, Anna Czarna

RyR2 regulates store-operated Ca²⁺ entry, phospholipase C activity, and electrical excitability in the insulinoma cell line INS-1

Kyle E. Harvey, Shiqi Tang, [ ... ], Gregory H. Hockerman

Parkin-mediated mitophagy is negatively regulated by FOXO3A, which inhibits Plk3-mediated mitochondrial ROS generation in STZ diabetic stress-treated pancreatic β cells

Ji Yeon Shim, Jin Ook Chung, [ ... ], SeungBaek Lee

Exploring the relationship between pancreatic fat and insulin secretion in overweight or obese women without type 2 diabetes mellitus: A preliminary investigation of the TOFI_Asia cohort

Ivana R. Sequeira, Wilson Yip, [ ... ], Sally D. Poppitt

A novel model of gestational diabetes: Acute high fat high sugar diet results in insulin resistance and beta cell dysfunction during pregnancy in mice

Akansha Mishra, Simone Hernandez Ruano, Pradip K. Saha, Kathleen A. Pennington

An intensity-based post-processing tool for 3D instance segmentation of organelles in soft X-ray tomograms

Angdi Li, Shuning Zhang, [ ... ], Liping Sun

Establishment of an enzyme-linked immunosorbent assay for mouse pancreatic polypeptide clarifies the regulatory mechanism of its secretion from pancreatic γ cells

Daisuke Saito, Yuko Nakagawa, [ ... ], Yoshio Fujitani

Increase in glycemic set point, alongside a decrease in waist circumference, in the non-diabetic population during the Japanese National Intervention Program for metabolic syndrome: A single-center, large-scale, matched-pair analysis

Takuya Sugiyama, Yuya Yamada, [ ... ], Yuji Matsuzawa

Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia

Rashmi Chandra, Dipendra K. Aryal, [ ... ], Rodger A. Liddle

Metabolic changes in vitamin D receptor knockout mice

Sue Lynn Lau, Rebecca A. Stokes, [ ... ], Jenny E. Gunton

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