Immunologic adjuvants

Relationship between protein conformational stability and its immunogenicity when administering antigens to mice using adjuvants—Analysis employed the CH₂ domain in human antibodies

Kosuke Oyama, Tadashi Ueda

published 22 Jul 2024

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Malaria transmission blocking activity of Anopheles stephensi alanyl aminopeptidase N antigen formulated with MPL, CpG, and QS21 adjuvants

Zeinab Pourhashem, Leila Nourani, Sakineh Pirahmadi, Hemn Yousefi, Jafar J. Sani, Abbasali Raz, Sedigheh Zakeri, Navid Dinparast Djadid, Akram Abouie Mehrizi

published 05 Jul 2024

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Bioinformatics design of a peptide vaccine containing sarcoma antigen NY-SAR-35 epitopes against breast cancer and evaluation of its immunological function in BALB/c mouse model

Nour Samman, Hassan Mohabatkar, Mandana Behbahani, Mazdak Ganjlikhani Hakemi

published 26 Jun 2024

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Protocol for a phase II study to evaluate the efficacy and safety of nivolumab as a postoperative adjuvant therapy for patients with esophageal cancer treated with preoperative docetaxel, cisplatin plus 5-fluorouracil treatment (PENTAGON trial)

Hironobu Goto, Taro Oshikiri, Takashi Kato, Yoshiaki Nagatani, Yohei Funakoshi, Yasufumi Koterazawa, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Hironobu Minami, Yoshihiro Kakeji

published 18 Apr 2024

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Immunogenic profile of a plant-produced nonavalent African horse sickness viral protein 2 (VP2) vaccine in IFNAR^-/^-mice

Martha M. O’Kennedy, Robyn Roth, Karen Ebersohn, Lissinda H. du Plessis, Sipho Mamputha, Daria A. Rutkowska, Ilse du Preez, Jan A. Verschoor, Yolandy Lemmer

published 16 Apr 2024

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Comparative study on alginate/chitosan microcapsules and Montanide ISA 61 as vaccine adjuvants in mice

Laice A. Silva, Monique F. Souza, Thaynara P. Carvalho, Clarissa H. Santana, Andressa C. Guedes, Jefferson Bruno S. Oliveira, Pâmela A. de Lima, Paulo Roberto A. Nogueira, Humberto de Mello Brandão, Tatiane A. da Paixão, Renato Lima Santos

published 04 Apr 2024

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Fusion of PspA to detoxified pneumolysin enhances pneumococcal vaccine coverage

Barbara Milani, Tanila Wood dos Santos, Maria Eduarda Souza Guerra, Sheila Oliveira, Cibelly Goulart, Greiciely O. André, Luciana C. C. Leite, Thiago R Converso, Michelle Darrieux

published 14 Dec 2023

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CHO-produced RBD-Fc subunit vaccines with alternative adjuvants generate immune responses against SARS-CoV-2

Sedthawut Laotee, Methawee Duangkaew, Araya Jivapetthai, Kittipan Tharakhet, Papatsara Kaewpang, Eakachai Prompetchara, Supaporn Phumiamorn, Sompong Sapsutthipas, Sakalin Trisiriwanich, Thitiporn Somsaard, Sittiruk Roytrakul, Parichat Duangkhae, Boonsri Ongpipattanakul, Patanachai Limpikirati, Natapol Pornputtapong, Wanatchaporn Arunmanee

published 14 Jul 2023

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In silico design and immunoinformatics analysis of a universal multi-epitope vaccine against monkeypox virus

Samira Sanami, Shahin Nazarian, Sajjad Ahmad, Elham Raeisi, Muhammad Tahir ul Qamar, Shahram Tahmasebian, Hamidreza Pazoki-Toroudi, Maryam Fazeli, Mahdi Ghatreh Samani

published 23 May 2023

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In silico design and validation of a novel multi-epitope vaccine candidate against structural proteins of Chikungunya virus using comprehensive immunoinformatics analyses

Shirin Mahmoodi, Javad Zamani Amirzakaria, Abdolmajid Ghasemian

published 05 May 2023

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Immunogenicity of a spike protein subunit-based COVID-19 vaccine with broad protection against various SARS-CoV-2 variants in animal studies

Ming-Chen Yang, Chun-Chung Wang, Wei-Chien Tang, Kuan-Ming Chen, Chu-Ying Chen, Hsiao-Han Lin, Yin-Cheng Hsieh, Nan-Hsuan Wang, Yin-Chieh Kuo, Ping-Tzu Chu, Hsin-Yi Tung, Yi-Chen Wu, Juo-Ling Sun, Sheng-Yu Liu, Wan-Fen Li, Wei-Han Lee, Jiann-Shiun Lai, Michael Chang, Ming-Tain Lai

published 24 Mar 2023

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The trehalose glycolipid C18Brar promotes antibody and T-cell immune responses to Mannheimia haemolytica and Mycoplasma ovipneumoniae whole cell antigens in sheep

Sandeep K. Gupta, Natalie Parlane, Benjamin Bridgeman, Amy T. Lynch, Emma M. Dangerfield, Mattie S. M. Timmer, Bridget L. Stocker, D. Neil Wedlock

published 19 Jan 2023

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Dose-sparing effect of two adjuvant formulations with a pandemic influenza A/H7N9 vaccine: A randomized, double-blind, placebo-controlled, phase 1 clinical trial

Tazio Vanni, Beatriz C. Thomé, Erin Sparrow, Martin Friede, Christopher B. Fox, Anna Marie Beckmann, Chuong Huynh, Gabriella Mondini, Daniela H. Silveira, Juliana Y. K. Viscondi, Patrícia Emilia Braga, Anderson da Silva, Maria da Graça Salomão, Roberta O. Piorelli, Joane P. Santos, Vera Lúcia Gattás, Maria Beatriz B. Lucchesi, Mayra M. M. de Oliveira, Marcelo E. Koike, Esper G. Kallas, Lucia M. A. Campos, Eduardo B. Coelho, Marilda A. M. Siqueira, Cristiana C. Garcia, Milene Dias Miranda, Terezinha M. Paiva, Maria do Carmo S. T. Timenetsky, Eduardo A. Adami, Milena A. Akamatsu, Paulo Lee Ho, Alexander R. Precioso

published 18 Oct 2022

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Immunologic adjuvants

Relationship between protein conformational stability and its immunogenicity when administering antigens to mice using adjuvants—Analysis employed the CH₂ domain in human antibodies

Malaria transmission blocking activity of Anopheles stephensi alanyl aminopeptidase N antigen formulated with MPL, CpG, and QS21 adjuvants

Bioinformatics design of a peptide vaccine containing sarcoma antigen NY-SAR-35 epitopes against breast cancer and evaluation of its immunological function in BALB/c mouse model

Protocol for a phase II study to evaluate the efficacy and safety of nivolumab as a postoperative adjuvant therapy for patients with esophageal cancer treated with preoperative docetaxel, cisplatin plus 5-fluorouracil treatment (PENTAGON trial)

Immunogenic profile of a plant-produced nonavalent African horse sickness viral protein 2 (VP2) vaccine in IFNAR^-/^-mice

Comparative study on alginate/chitosan microcapsules and Montanide ISA 61 as vaccine adjuvants in mice

Fusion of PspA to detoxified pneumolysin enhances pneumococcal vaccine coverage

CHO-produced RBD-Fc subunit vaccines with alternative adjuvants generate immune responses against SARS-CoV-2

In silico design and immunoinformatics analysis of a universal multi-epitope vaccine against monkeypox virus

In silico design and validation of a novel multi-epitope vaccine candidate against structural proteins of Chikungunya virus using comprehensive immunoinformatics analyses

Immunogenicity of a spike protein subunit-based COVID-19 vaccine with broad protection against various SARS-CoV-2 variants in animal studies

The trehalose glycolipid C18Brar promotes antibody and T-cell immune responses to Mannheimia haemolytica and Mycoplasma ovipneumoniae whole cell antigens in sheep

Dose-sparing effect of two adjuvant formulations with a pandemic influenza A/H7N9 vaccine: A randomized, double-blind, placebo-controlled, phase 1 clinical trial

Immunologic adjuvants

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