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Immune system

Human antibodies against Mycobacterium avium ssp. paratuberculosis combined with cytokine levels for the diagnosis and selection of Crohn’s disease patients for anti-mycobacterial therapy—A pilot study

J. Todd Kuenstner, Peilin Zhang, Raghava Potula, Jean-Michel Galarneau, Horacio Bach

published 04 Oct 2024

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PVAT-conditioned media from Dahl S rats on high fat diet promotes inflammatory cytokine secretion by activated T cells prior to the development of hypertension

Yining Jin, Sheng Liu, Kimberly E. Guzmán, Ramya K. Kumar, Luca M. Kaiser, Hannah Garver, Jamie J. Bernard, Sudin Bhattacharya, Gregory D. Fink, Stephanie W. Watts, Cheryl E. Rockwell

published 03 Oct 2024

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Energy demanding RNA and protein metabolism drive dysfunctionality of HIV-specific T cell changes during chronic HIV infection

Lisa van Pul, Melissa Stunnenberg, Stefanie Kroeze, Karel A. van Dort, Brigitte D. M. Boeser-Nunnink, Agnes M. Harskamp, Teunis B. H. Geijtenbeek, Neeltje A. Kootstra

published 02 Oct 2024

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The heat shock protein 90 inhibitor RGRN-305 attenuates SARS-CoV-2 spike protein-induced inflammation in vitro but lacks effectiveness as COVID-19 treatment in mice

Hakim Ben Abdallah, Giorgia Marino, Manja Idorn, Line S. Reinert, Anne Bregnhøj, Søren Riis Paludan, Claus Johansen

published 26 Sep 2024

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Lawsonia intracellularis regulates nuclear factor-κB signalling pathway during infection

Huan W. Yang, Tuanjun Hu, Tahar Ait-Ali

published 26 Sep 2024

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Advancing one health vaccination: In silico design and evaluation of a multi-epitope subunit vaccine against Nipah virus for cross-species immunization using immunoinformatics and molecular modeling

Edward Coralde Banico, Ella Mae Joy Sinco Sira, Lauren Emily Fajardo, Albert Neil Gura Dulay, Nyzar Mabeth Obenio Odchimar, Alea Maurice Simbulan, Fredmoore Legaspi Orosco

published 26 Sep 2024

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Shared fate was associated with sustained cooperation during the COVID-19 pandemic

Diego Guevara Beltran, Jessica D. Ayers, Scott Claessens, Joe Alcock, Cristina Baciu, Lee Cronk, Nicole M. Hudson, Hector Hurmuz-Sklias, Geoffrey Miller, Keith Tidball, Andrew Van Horn, Pamela Winfrey, Emily Zarka, Peter M. Todd, Athena Aktipis

published 26 Sep 2024

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Serum-deprivation response of ARPE-19 cells; expression patterns relevant to age-related macular degeneration

Katherine M. Peterson, Sanghamitra Mishra, Esther Asaki, John I. Powell, Yiwen He, Alan E. Berger, Dinusha Rajapakse, Graeme Wistow

published 26 Sep 2024

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TFAB002s, novel CD20-targeting T cell-dependent bispecific Fab-FabCH3 antibodies, exhibit potent antitumor efficacy against malignant B-cell lymphoma

Qinghong Li, Kunming Zhang, Yao Yu, Zeng Yu, Jingyi Xu, Wenyan Shen, Lin Zhang, Aidong Qu, Hongyuan Liang

published 25 Sep 2024

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In vitro toxicity assessment of bioavailable iron in coal varieties of Central India

Ruchika Kishor Jain, Anshumali, Prasad Sherekar, Amit Nayak, Shraddha Jaiswal, Komal Pimpalghare, Rajani Tumane, Aruna Jawade, Shubhangi Kailas Pingle, Sanvidhan G. Suke, Rajpal Singh Kashyap, Bibhuti Bhusan Mandal

published 19 Sep 2024

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PDE5 inhibitor potentially improves polyuria and bladder storage and voiding dysfunctions in type 2 diabetic rats

Takafumi Kabuto, So Inamura, Hisato Kobayashi, Xinmin Zha, Keiko Nagase, Minekatsu Taga, Masaya Seki, Nobuki Tanaka, Yoshinaga Okumura, Osamu Yokoyama, Naoki Terada

published 18 Sep 2024

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Geniposide ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β/Smad and p38MAPK signaling pathways

Jian-Bin Yin, Ying-Xia Wang, Su-Su Fan, Wen-Bin Shang, Yu-Shan Zhu, Xue-Rong Peng, Cheng Zou, Xuan Zhang

published 06 Sep 2024

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Curcumin alleviates heatstroke-induced liver injury in dry-heat environments by inhibiting the expression of NF-κB, iNOS, and ICAM-1 in rats

Xinyue Yang, Liang Xia, Caifu Shen, Jiajia Li, Xiang Dong, Jiangwei Liu

published 06 Sep 2024

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