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High throughput screening

Comparing Chemistry to Outcome: The Development of a Chemical Distance Metric, Coupled with Clustering and Hierarchal Visualization Applied to Macromolecular Crystallography

Andrew E. Bruno, Amanda M. Ruby, [ ... ], Edward H. Snell

A High Throughput Screen Identifies Potent and Selective Inhibitors to Human Epithelial 15-Lipoxygenase-2

J. Brian Jameson II, Auric Kantz, [ ... ], Theodore R. Holman

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling

Martin Liss, Michael H. Radke, [ ... ], Michael Gotthardt

Molecular Engineering of Fungal GH5 and GH26 Beta-(1,4)-Mannanases toward Improvement of Enzyme Activity

Marie Couturier, Julia Féliu, [ ... ], Jean-Guy Berrin

Discovery of an Inhibitor of Z-Alpha1 Antitrypsin Polymerization

Valerie Berthelier, Jason Brett Harris, Kasey Noel Estenson, Jerome Baudry

Kinetic Characterization and Allosteric Inhibition of the Yersinia pestis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (MEP Synthase)

Amanda Haymond, Chinchu Johny, [ ... ], Robin D. Couch

Clinically relevant inflammatory breast cancer patient-derived xenograft–derived ex vivo model for evaluation of tumor-specific therapies

Bedrich L. Eckhardt, Maria Gagliardi, [ ... ], Geoffrey A. Bartholomeusz

Kinetic Analysis of Yersinia pestis DNA Adenine Methyltransferase Activity Using a Hemimethylated Molecular Break Light Oligonucleotide

Robert J. Wood, Michael D. Maynard-Smith, [ ... ], Peter L. Roach

A highly-sensitive high throughput assay for dynamin's basal GTPase activity

Aparna Mohanakrishnan, Triet Vincent M. Tran, [ ... ], Sandra L. Schmid

A high-throughput newborn screening approach for SCID, SMA, and SCD combining multiplex qPCR and tandem mass spectrometry

Rafael Tesorero, Joachim Janda, [ ... ], Jürgen G. Okun

Chemoinformatic Identification of Novel Inhibitors against Mycobacterium tuberculosis L-aspartate α-decarboxylase

Reetu Sharma, Roopa Kothapalli, Antonius M. J. Van Dongen, Kunchithapadam Swaminathan

A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis

Lauren Forbes, Katherine Ebsworth-Mojica, [ ... ], Damian J. Krysan

Screening for AMPA receptor auxiliary subunit specific modulators

Caleigh M. Azumaya, Emily L. Days, [ ... ], Terunaga Nakagawa

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