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High throughput screening

An Enzymatic Assay for High-Throughput Screening of Cytidine-Producing Microbial Strains

Huina Dong, Yongfei Liu, Xin Zu, Ning Li, Feiran Li, Dawei Zhang

published 27 Mar 2015

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Identification of Small Molecules that Disrupt Signaling between ABL and Its Positive Regulator RIN1

Pamela Y. Ting, Robert Damoiseaux, Björn Titz, Kenneth A. Bradley, Thomas G. Graeber, Virneliz Fernández-Vega, Thomas D. Bannister, Peter Chase, Reji Nair, Louis Scampavia, Peter Hodder, Timothy P. Spicer, John Colicelli

published 26 Mar 2015

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Global Analysis Reveals Families of Chemical Motifs Enriched for hERG Inhibitors

Fang Du, Joseph J. Babcock, Haibo Yu, Beiyan Zou, Min Li

published 20 Feb 2015

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A High-Throughput Cidality Screen for Mycobacterium Tuberculosis

Parvinder Kaur, Anirban Ghosh, Ramya Vadageri Krishnamurthy, Deepa Gagwani Bhattacharjee, Vijayashree Achar, Santanu Datta, Shridhar Narayanan, Anand Anbarasu, Sudha Ramaiah

published 18 Feb 2015

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Combining Motion Analysis and Microfluidics – A Novel Approach for Detecting Whole-Animal Responses to Test Substances

Tabitha S. Rudin-Bitterli, Oliver Tills, John I. Spicer, Phil F. Culverhouse, Eric M. Wielhouwer, Michael K. Richardson, Simon D. Rundle

published 02 Dec 2014

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An Automated High-Throughput Cell-Based Multiplexed Flow Cytometry Assay to Identify Novel Compounds to Target Candida albicans Virulence-Related Proteins

Stella M. Bernardo, Christopher P. Allen, Anna Waller, Susan M. Young, Tudor Oprea, Larry A. Sklar, Samuel A. Lee

published 28 Oct 2014

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Suramin Inhibits Hsp104 ATPase and Disaggregase Activity

Mariana P. Torrente, Laura M. Castellano, James Shorter

published 09 Oct 2014

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Kinetic Characterization and Allosteric Inhibition of the Yersinia pestis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (MEP Synthase)

Amanda Haymond, Chinchu Johny, Tyrone Dowdy, Brandon Schweibenz, Karen Villarroel, Richard Young, Clark J. Mantooth, Trishal Patel, Jessica Bases, Geraldine San Jose, Emily R. Jackson, Cynthia S. Dowd, Robin D. Couch

published 29 Aug 2014

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Acute Effects of TiO₂ Nanomaterials on the Viability and Taxonomic Composition of Aquatic Bacterial Communities Assessed via High-Throughput Screening and Next Generation Sequencing

Chu Thi Thanh Binh, Tiezheng Tong, Jean-François Gaillard, Kimberly A. Gray, John J. Kelly

published 27 Aug 2014

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A Robust and Adaptable High Throughput Screening Method to Study Host-Microbiota Interactions in the Human Intestine

Tomas de Wouters, Florence Ledue, Malgorzata Nepelska, Joël Doré, Hervé M. Blottière, Nicolas Lapaque

published 20 Aug 2014

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A High Throughput Screen Identifies Potent and Selective Inhibitors to Human Epithelial 15-Lipoxygenase-2

J. Brian Jameson II, Auric Kantz, Lena Schultz, Chakrapani Kalyanaraman, Matthew P. Jacobson, David J. Maloney, Ajit Jadhav, Anton Simeonov, Theodore R. Holman

published 11 Aug 2014

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A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein

Joseph Carver, Thomas S. Dexheimer, Dennis Hsu, Meng-Tzu Weng, Jordan L. Smith, Rajarshi Guha, Ajit Jadhav, Anton Simeonov, Ji Luo

published 05 Aug 2014

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Comparing Chemistry to Outcome: The Development of a Chemical Distance Metric, Coupled with Clustering and Hierarchal Visualization Applied to Macromolecular Crystallography

Andrew E. Bruno, Amanda M. Ruby, Joseph R. Luft, Thomas D. Grant, Jayaraman Seetharaman, Gaetano T. Montelione, John F. Hunt, Edward H. Snell

published 27 Jun 2014

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