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High throughput screening

A High-Throughput Cell-Based Screen Identified a 2-[(E)-2-Phenylvinyl]-8-Quinolinol Core Structure That Activates p53

John Bechill, Rong Zhong, Chen Zhang, Elena Solomaha, Michael T. Spiotto

published 28 Apr 2016

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High Throughput Screen for Escherichia coli Twin Arginine Translocation (Tat) Inhibitors

Umesh K. Bageshwar, Lynn VerPlank, Dwight Baker, Wen Dong, Shruthi Hamsanathan, Neal Whitaker, James C. Sacchettini, Siegfried M. Musser

published 22 Feb 2016

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Synergistic Malaria Parasite Killing by Two Types of Plasmodial Surface Anion Channel Inhibitors

Margaret Pain, Alexandra W. Fuller, Katherine Basore, Ajay D. Pillai, Tsione Solomon, Abdullah A. B. Bokhari, Sanjay A. Desai

published 11 Feb 2016

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When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis

Jack W. Scannell, Jim Bosley

published 10 Feb 2016

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Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice

Michael S. Boosalis, Jose I. Sangerman, Gary L. White, Roman F. Wolf, Ling Shen, Yan Dai, Emily White, Levi H. Makala, Biaoru Li, Betty S. Pace, Mehdi Nouraie, Douglas V. Faller, Susan P. Perrine

published 29 Dec 2015

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Thermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound Conformation

Evan M. Green, Jonathan A. Coleman, Eric Gouaux

published 22 Dec 2015

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High-Throughput Screening of Myometrial Calcium-Mobilization to Identify Modulators of Uterine Contractility

Jennifer L. Herington, Daniel R. Swale, Naoko Brown, Elaine L. Shelton, Hyehun Choi, Charles H. Williams, Charles C. Hong, Bibhash C. Paria, Jerod S. Denton, Jeff Reese

published 24 Nov 2015

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Flow-Based Single Cell Deposition for High-Throughput Screening of Protein Libraries

Cassandra Stowe, Arnold Pizzey, Tammy Kalber, Adam Badar, Mark Lythgoe, Martin Pule

published 04 Nov 2015

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High-Throughput Screening for Ligands of the HEPN Domain of Sacsin

Xinlu Li, Marie Ménade, Guennadi Kozlov, Zheping Hu, Zheng Dai, Peter S. McPherson, Bernard Brais, Kalle Gehring

published 14 Sep 2015

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High Throughput Screening Method to Explore Protein Interactions with Nanoparticles

Irem Nasir, Warda Fatih, Anja Svensson, Dennis Radu, Sara Linse, Celia Cabaleiro Lago, Martin Lundqvist

published 27 Aug 2015

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A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis

Lauren Forbes, Katherine Ebsworth-Mojica, Louis DiDone, Shao-Gang Li, Joel S. Freundlich, Nancy Connell, Paul M. Dunman, Damian J. Krysan

published 22 Jun 2015

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Discovery of an Inhibitor of Z-Alpha1 Antitrypsin Polymerization

Valerie Berthelier, Jason Brett Harris, Kasey Noel Estenson, Jerome Baudry

published 11 May 2015

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Optimization of a Fluorescence-Based Assay for Large-Scale Drug Screening against Babesia and Theileria Parasites

Mohamed Abdo Rizk, Shimaa Abd El-Salam El-Sayed, Mohamed Alaa Terkawi, Mohamed Ahmed Youssef, El Said El Shirbini El Said, Gehad Elsayed, Sabry El-Khodery, Maged El-Ashker, Ahmed Elsify, Mosaab Omar, Akram Salama, Naoaki Yokoyama, Ikuo Igarashi

published 27 Apr 2015

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