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High throughput screening

Assessment of p.Phe508del-CFTR functional restoration in pediatric primary cystic fibrosis airway epithelial cells

Erika N. Sutanto, Amelia Scaffidi, Luke W. Garratt, Kevin Looi, Clara J. Foo, Michela A. Tessari, Richard A. Janssen, David F. Fischer, Stephen M. Stick, Anthony Kicic, on behalf of AREST CF

published 23 Jan 2018

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Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity

Michael Wormald, Gangling Liao, Martha Kimos, James Barrow, Huijun Wei

published 29 Nov 2017

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Mechanisms of action of Coxiella burnetii effectors inferred from host-pathogen protein interactions

Anders Wallqvist, Hao Wang, Nela Zavaljevski, Vesna Memišević, Keehwan Kwon, Rembert Pieper, Seesandra V. Rajagopala, Jaques Reifman

published 27 Nov 2017

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Identification of small molecules uncoupling the Notch::Jagged interaction through an integrated high-throughput screening

Natalia Platonova, Chiara Parravicini, Cristina Sensi, Alessandro Paoli, Michela Colombo, Antonino Neri, Ivano Eberini, Raffaella Chiaramonte

published 03 Nov 2017

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A highly-sensitive high throughput assay for dynamin's basal GTPase activity

Aparna Mohanakrishnan, Triet Vincent M. Tran, Meera Kumar, Hong Chen, Bruce A. Posner, Sandra L. Schmid

published 28 Sep 2017

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Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay

Justin Hall, Amy Brault, Fabien Vincent, Shawn Weng, Hong Wang, Darren Dumlao, Ann Aulabaugh, Dikran Aivazian, Dana Castro, Ming Chen, Jeffrey Culp, Ken Dower, Joseph Gardner, Steven Hawrylik, Douglas Golenbock, David Hepworth, Mark Horn, Lyn Jones, Peter Jones, Eicke Latz, Jing Li, Lih-Ling Lin, Wen Lin, David Lin, Frank Lovering, Nootaree Niljanskul, Ryan Nistler, Betsy Pierce, Olga Plotnikova, Daniel Schmitt, Suman Shanker, James Smith, William Snyder, Timothy Subashi, John Trujillo, Edyta Tyminski, Guoxing Wang, Jimson Wong, Bruce Lefker, Leslie Dakin, Karen Leach

published 21 Sep 2017

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Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors

Weimei Xing, Ona Barauskas, Thorsten Kirschberg, Anita Niedziela-Majka, Michael Clarke, Gabriel Birkus, Perry Weissburg, Xiaohong Liu, Brian E. Schultz, Roman Sakowicz, HyockJoo Kwon, Joy Y. Feng

published 15 Aug 2017

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Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes

Thomas A. Ward, Peter J. McHugh, Stephen T. Durant

published 19 Jun 2017

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Designing small molecules to target cryptic pockets yields both positive and negative allosteric modulators

Kathryn M. Hart, Katelyn E. Moeder, Chris M. W. Ho, Maxwell I. Zimmerman, Thomas E. Frederick, Gregory R. Bowman

published 01 Jun 2017

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Improvement of uridine production of Bacillus subtilis by atmospheric and room temperature plasma mutagenesis and high-throughput screening

Xiaoguang Fan, Heyun Wu, Guoliang Li, Hui Yuan, Hongchao Zhang, Yanjun Li, Xixian Xie, Ning Chen

published 04 May 2017

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Screening for AMPA receptor auxiliary subunit specific modulators

Caleigh M. Azumaya, Emily L. Days, Paige N. Vinson, Shaun Stauffer, Gary Sulikowski, C. David Weaver, Terunaga Nakagawa

published 30 Mar 2017

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Application of 2,4-Dinitrophenylhydrazine (DNPH) in High-Throughput Screening for Microorganism Mutants Accumulating 9α-Hydroxyandrost-4-ene-3,17-dione (9α-OH-AD)

Yang Liu, Fei Cao, Hui Xiong, Yanbing Shen, Min Wang

published 05 Oct 2016

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Fully-Automated High-Throughput NMR System for Screening of Haploid Kernels of Maize (Corn) by Measurement of Oil Content

Hongzhi Wang, Jin Liu, Xiaoping Xu, Qingming Huang, Shanshan Chen, Peiqiang Yang, Shaojiang Chen, Yiqiao Song

published 25 Jul 2016

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