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High throughput screening

A high-throughput, whole cell assay to identify compounds active against carbapenem-resistant Klebsiella pneumoniae

Julie Liao, George Xu, Emily E. Mevers, Jon Clardy, Paula I. Watnick

published 21 Dec 2018

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Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway

Wolfgang Klein, Claudia Rutz, Jamina Eckhard, Becky Provinciael, Edgar Specker, Martin Neuenschwander, Gunnar Kleinau, Patrick Scheerer, Jens-Peter von Kries, Marc Nazaré, Kurt Vermeire, Ralf Schülein

published 13 Dec 2018

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Deformable 96-well cell culture plate compatible with high-throughput screening platforms

Tsubasa S. Matsui, Hugejile Wu, Shinji Deguchi

published 06 Sep 2018

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Modulating D-amino acid oxidase (DAAO) substrate specificity through facilitated solvent access

Kalyanasundaram Subramanian, Artur Góra, Ruud Spruijt, Karolina Mitusińska, Maria Suarez-Diez, Vitor Martins dos Santos, Peter J. Schaap

published 15 Jun 2018

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OG716: Designing a fit-for-purpose lantibiotic for the treatment of Clostridium difficile infections

Johan A. Kers, Anthony W. DeFusco, Jae H. Park, Jin Xu, Mark E. Pulse, William J. Weiss, Martin Handfield

published 12 Jun 2018

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Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling

Martin Liss, Michael H. Radke, Jamina Eckhard, Martin Neuenschwander, Vita Dauksaite, Jens-Peter von Kries, Michael Gotthardt

published 11 Jun 2018

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High-throughput screening system for dynamic monitoring of exocytotic vesicle trafficking in mast cells

Takeshi Kiyoi, Shuang Liu, Muhammad Novrizal Abdi Sahid, Masachika Shudou, Kazutaka Maeyama, Masaki Mogi

published 08 Jun 2018

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Clinically relevant inflammatory breast cancer patient-derived xenograft–derived ex vivo model for evaluation of tumor-specific therapies

Bedrich L. Eckhardt, Maria Gagliardi, LaKesla Iles, Kurt Evans, Cristina Ivan, Xiuping Liu, Chang-Gong Liu, Glauco Souza, Arvind Rao, Funda Meric-Bernstam, Naoto T. Ueno, Geoffrey A. Bartholomeusz

published 16 May 2018

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A high-throughput 3’ UTR reporter screening identifies microRNA interactomes of cancer genes

Gert Van Peer, Evelien Mets, Shana Claeys, Ines De Punt, Steve Lefever, Maté Ongenaert, Pieter Rondou, Frank Speleman, Pieter Mestdagh, Jo Vandesompele

published 09 Mar 2018

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Xenopus: An alternative model system for identifying muco-active agents

Hyo Jung Sim, Sang-Hyun Kim, Kyung-Jae Myung, Taejoon Kwon, Hyun-Shik Lee, Tae Joo Park

published 22 Feb 2018

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Assessment of p.Phe508del-CFTR functional restoration in pediatric primary cystic fibrosis airway epithelial cells

Erika N. Sutanto, Amelia Scaffidi, Luke W. Garratt, Kevin Looi, Clara J. Foo, Michela A. Tessari, Richard A. Janssen, David F. Fischer, Stephen M. Stick, Anthony Kicic, on behalf of AREST CF

published 23 Jan 2018

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Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity

Michael Wormald, Gangling Liao, Martha Kimos, James Barrow, Huijun Wei

published 29 Nov 2017

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Mechanisms of action of Coxiella burnetii effectors inferred from host-pathogen protein interactions

Anders Wallqvist, Hao Wang, Nela Zavaljevski, Vesna Memišević, Keehwan Kwon, Rembert Pieper, Seesandra V. Rajagopala, Jaques Reifman

published 27 Nov 2017

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