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High throughput screening

High-throughput screen in vitro identifies dasatinib as a candidate for combinatorial treatment with HER2-targeting drugs in breast cancer

Lisa Svartdal Normann, Mads Haugland Haugen, Vesa Hongisto, Miriam Ragle Aure, Suvi-Katri Leivonen, Vessela N. Kristensen, Andliena Tahiri, Olav Engebraaten, Kristine Kleivi Sahlberg, Gunhild Mari Mælandsmo

published 27 Jan 2023

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Floating sphere assay: A rapid qualitative method for microvolume analysis of gelation

Uma Jingxin Tay, Megan Goh, Jeralyn Ching Wen Hui, Prakash Arumugam

published 08 Jul 2022

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In silico approaches for drug repurposing in oncology: Protocol for a scoping review of existing evidence

Bruno Raphael Ribeiro Cavalcante, Raíza Dias Freitas, Leonardo de Oliveira Siquara da Rocha, Gisele Vieira Rocha, Túlio Cosme de Carvalho Pachêco, Pablo Ivan Pereira Ramos, Clarissa Araújo Gurgel Rocha

published 07 Jul 2022

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A gene expression biomarker for predictive toxicology to identify chemical modulators of NF-κB

Katharine L. Korunes, Jie Liu, Ruili Huang, Menghang Xia, Keith A. Houck, J. Christopher Corton

published 02 Feb 2022

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Identification of genes involved in exoprotein release using a high-throughput exoproteome screening assay in Yersinia entomophaga

Marion Schoof, Maureen O’Callaghan, Campbell R. Sheen, Travis R. Glare, Mark R. H. Hurst

published 25 Jan 2022

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Drug screening to identify compounds to act as co-therapies for the treatment of Burkholderia species

Sam Barker, Sarah V. Harding, David Gray, Mark I. Richards, Helen S. Atkins, Nicholas J. Harmer

published 25 Mar 2021

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OpenStats: A robust and scalable software package for reproducible analysis of high-throughput phenotypic data

Hamed Haselimashhadi, Jeremy C. Mason, Ann-Marie Mallon, Damian Smedley, Terrence F. Meehan, Helen Parkinson

published 30 Dec 2020

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Double antibody pairs sandwich-ELISA (DAPS-ELISA) detects Acidovorax citrulli serotypes with broad coverage

Orawan Himananto, Kirana Yoohat, Kannawat Danwisetkanjana, Mallika Kumpoosiri, Sombat Rukpratanporn, Yada Theppawong, Sudtida Phuengwas, Manlika Makornwattana, Ratthaphol Charlermroj, Nitsara Karoonuthaisiri, Petcharat Thummabenjapone, Nuttima Kositcharoenkul, Oraprapai Gajanandana

published 27 Aug 2020

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A cell-based high-throughput screen identifies inhibitors that overcome P-glycoprotein (Pgp)-mediated multidrug resistance

Rida Zahra, Muhammad Furqan, Rahim Ullah, Aziz Mithani, Rahman Shah Zaib Saleem, Amir Faisal

published 02 Jun 2020

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Optimized criteria for locomotion-based healthspan evaluation in C. elegans using the WorMotel system

Areta Jushaj, Matthew Churgin, Bowen Yao, Miguel De La Torre, Christopher Fang-Yen, Liesbet Temmerman

published 03 Mar 2020

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Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase

Leah S. Torrie, Fabio Zuccotto, David A. Robinson, David W. Gray, Ian H. Gilbert, Manu De Rycker

published 31 May 2019

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Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions

Gregory S. Honda, Robert G. Pearce, Ly L. Pham, R. W. Setzer, Barbara A. Wetmore, Nisha S. Sipes, Jon Gilbert, Briana Franz, Russell S. Thomas, John F. Wambaugh

published 28 May 2019

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High content analysis enables high-throughput nematicide discovery screening for measurement of viability and movement behavior in response to natural product samples

Jennifer M. Petitte, Mary H. Lewis, Tucker K. Witsil, Xiang Huang, John W. Rice

published 23 Apr 2019

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