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High throughput screening

Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε

Jessica E. Hutti, Melissa A. Porter, Adam W. Cheely, Lewis C. Cantley, Xiaodong Wang, Dmitri Kireev, Albert S. Baldwin, William P. Janzen

published 30 Jul 2012

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High-throughput Screening and Sensitized Bacteria Identify an M. tuberculosis Dihydrofolate Reductase Inhibitor with Whole Cell Activity

Anuradha Kumar, Meng Zhang, Linyun Zhu, Reiling P. Liao, Charles Mutai, Shittu Hafsat, David R. Sherman, Ming-Wei Wang

published 29 Jun 2012

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A FRET-Based High Throughput Screening Assay to Identify Inhibitors of Anthrax Protective Antigen Binding to Capillary Morphogenesis Gene 2 Protein

Michael S. Rogers, Lorna M. Cryan, Kaiane A. Habeshian, Lauren Bazinet, Thomas P. Caldwell, P. Christine Ackroyd, Kenneth A. Christensen

published 29 Jun 2012

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Chemoinformatic Identification of Novel Inhibitors against Mycobacterium tuberculosis L-aspartate α-decarboxylase

Reetu Sharma, Roopa Kothapalli, Antonius M. J. Van Dongen, Kunchithapadam Swaminathan

published 28 Mar 2012

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A Fluorescence-Based High-Throughput Assay for the Discovery of Exchange Protein Directly Activated by Cyclic AMP (EPAC) Antagonists

Tamara Tsalkova, Fang C. Mei, Xiaodong Cheng

published 19 Jan 2012

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Targeting Acetylcholinesterase: Identification of Chemical Leads by High Throughput Screening, Structure Determination and Molecular Modeling

Lotta Berg, C. David Andersson, Elisabet Artursson, Andreas Hörnberg, Anna-Karin Tunemalm, Anna Linusson, Fredrik Ekström

published 30 Nov 2011

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A Simple Protocol for Using a LDH-Based Cytotoxicity Assay to Assess the Effects of Death and Growth Inhibition at the Same Time

Shilo M. Smith, Michael B. Wunder, David A. Norris, Yiqun G. Shellman

published 17 Nov 2011

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High-Throughput Assay for the Identification of Compounds Regulating Osteogenic Differentiation of Human Mesenchymal Stromal Cells

Hugo Alves, Koen Dechering, Clemens Van Blitterswijk, Jan De Boer

published 26 Oct 2011

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A System for Performing High Throughput Assays of Synaptic Function

Chris M. Hempel, Michael Sivula, Jonathan M. Levenson, David M. Rose, Bing Li, Ana C. Sirianni, Eva Xia, Timothy A. Ryan, David J. Gerber, Jeffrey R. Cottrell

published 05 Oct 2011

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New Classes of Alanine Racemase Inhibitors Identified by High-Throughput Screening Show Antimicrobial Activity against Mycobacterium tuberculosis

Karen G. Anthony, Ulrich Strych, Kacheong R. Yeung, Carolyn S. Shoen, Oriana Perez, Kurt L. Krause, Michael H. Cynamon, Paul A. Aristoff, Raymond A. Koski

published 26 May 2011

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A High Throughput Screen Identifies Chemical Modulators of the Laminin-Induced Clustering of Dystroglycan and Aquaporin-4 in Primary Astrocytes

Geoffroy Noël, Sarah Stevenson, Hakima Moukhles

published 07 Mar 2011

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Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

Oliver N. F. King, Xuan Shirley Li, Masaaki Sakurai, Akane Kawamura, Nathan R. Rose, Stanley S. Ng, Amy M. Quinn, Ganesha Rai, Bryan T. Mott, Paul Beswick, Robert J. Klose, Udo Oppermann, Ajit Jadhav, Tom D. Heightman, David J. Maloney, Christopher J. Schofield, Anton Simeonov

published 23 Nov 2010

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High-Affinity Inhibitors of Human NAD⁺-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships

Frank H. Niesen, Lena Schultz, Ajit Jadhav, Chitra Bhatia, Kunde Guo, David J. Maloney, Ewa S. Pilka, Minghua Wang, Udo Oppermann, Tom D. Heightman, Anton Simeonov

published 02 Nov 2010

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