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High throughput screening

A Simple Protocol for Using a LDH-Based Cytotoxicity Assay to Assess the Effects of Death and Growth Inhibition at the Same Time

Shilo M. Smith, Michael B. Wunder, David A. Norris, Yiqun G. Shellman

When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis

Jack W. Scannell, Jim Bosley

Development of Multicellular Tumor Spheroid (MCTS) Culture from Breast Cancer Cell and a High Throughput Screening Method Using the MTT Assay

Wan Yong Ho, Swee Keong Yeap, [ ... ], Noorjahan Banu Alitheen

A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN)

Joshua A. Sommers, Tomasz Kulikowicz, [ ... ], Robert M. Brosh Jr.

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay

Justin Hall, Amy Brault, [ ... ], Karen Leach

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

Oliver N. F. King, Xuan Shirley Li, [ ... ], Anton Simeonov

A Comparison of Protein Kinases Inhibitor Screening Methods Using Both Enzymatic Activity and Binding Affinity Determination

Amalie Frederikke Rudolf, Tine Skovgaard, [ ... ], Jens Berthelsen

Targeting Fatty Acid Binding Protein (FABP) Anandamide Transporters – A Novel Strategy for Development of Anti-Inflammatory and Anti-Nociceptive Drugs

William T. Berger, Brian P. Ralph, [ ... ], Dale G. Deutsch

A FRET-Based High Throughput Screening Assay to Identify Inhibitors of Anthrax Protective Antigen Binding to Capillary Morphogenesis Gene 2 Protein

Michael S. Rogers, Lorna M. Cryan, [ ... ], Kenneth A. Christensen

Functional Metagenomics: A High Throughput Screening Method to Decipher Microbiota-Driven NF-κB Modulation in the Human Gut

Omar Lakhdari, Antonietta Cultrone, [ ... ], Hervé M. Blottière

Inhibitors of the Influenza A Virus M2 Proton Channel Discovered Using a High-Throughput Yeast Growth Restoration Assay

Aruna D. Balgi, Jun Wang, [ ... ], Michel Roberge

High-Affinity Inhibitors of Human NAD⁺-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships

Frank H. Niesen, Lena Schultz, [ ... ], Anton Simeonov

Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes

Thomas A. Ward, Peter J. McHugh, Stephen T. Durant

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