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Genome engineering

Off-target sequence variations driven by the intrinsic properties of the Cas–sgRNA–DNA complex in genome editing

Celine Kurniawan, Takeshi Itoh

Comparative genomics of Lentilactobacillus buchneri reveals strain-level hyperdiversity and broad-spectrum CRISPR immunity against human and livestock gut phages

Ismail Gumustop, Ibrahim Genel, Ibrahim Cagri Kurt, Fatih Ortakci

The genome of Gallaecimonas pentaromativorans strain 10A, isolated from a Pacific oyster, sheds light on an environmentally widespread genus with remarkable metabolic potential

Yasmine Gouin, Adam Wilcockson, [ ... ], Kevin Xu Zhong

Different paths, same destination, yet diverse effects: Antecedent configurations and performance implications of digital transformation in pharmaceutical manufacturing enterprises——Evidence from Chinese listed companies

Bingxiao Shi, Chunlan Mou, Yiwen Zhang, Tiantian Cui

Development of a novel and viable knock-in factor V deficiency murine model: Utility for an ultra-rare disease

Juan A. De Pablo-Moreno, Leopoldo González-Brusi, [ ... ], Antonio Liras

Evolution of talent policies in Guangdong-Hong Kong-Macao greater bay area: An LDA thematic model approach

Jinpeng Wen, Hongxing Han

Anti-cancer compound screening identifies Aurora Kinase A inhibition as a means to favor CRISPR/Cas9 gene correction over knock-out

Danny Wilbie, Selma Eising, [ ... ], Enrico Mastrobattista

Investigating the impact of type I-E CRISPR-Cas systems and acrEI10 on multidrug-resistance in clinical isolates of Klebsiella pneumoniae

Maryam Siroosi, Fatemeh Ghasemi, [ ... ], Mohammad Ali Amoozegar

Omics-aided design genome editing strategy for challenging human immortalized cell models

Patricia Mendoza-Garcia, Benjamin Keith, [ ... ], Xiang Zhang

Carbon nanotube and carbon dot mediated plasmid DNA delivery in cowpea leaves

Merve Saglam, Nikolaos Tsakirpaloglou, [ ... ], Endang M. Septiningsih

A VPS33B CRISPR knockout study: In vitro evidence of an adhesion defect

Maria Caluianu, Kimberley A. Owen

Single-tube two-step RPA-CRISPR/Cas12b platform for detection of Pseudomonas aeruginosa

Haotian Lin, Shichun Wang, [ ... ], Hongxing Zhang

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