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Genome engineering

A CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLC

Nicholas Dompe, Christiaan Klijn, Sara A. Watson, Katherine Leng, Jenna Port, Trinna Cuellar, Colin Watanabe, Benjamin Haley, Richard Neve, Marie Evangelista, David Stokoe

published 18 Jun 2018

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Reemergence of human plague in Yunnan, China in 2016

Liyuan Shi, Guirong Yang, Zhikai Zhang, Lianxu Xia, Ying Liang, Hongli Tan, Jinrong He, Jianguo Xu, Zhizhong Song, Wei Li, Peng Wang

published 13 Jun 2018

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DMSO increases efficiency of genome editing at two non-coding loci

George Stratigopoulos, Maria Caterina De Rosa, Charles A. LeDuc, Rudolph L. Leibel, Claudia A. Doege

published 04 Jun 2018

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Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation

Michael J. Thomenius, Jennifer Totman, Darren Harvey, Lorna H. Mitchell, Thomas V. Riera, Kat Cosmopoulos, Alexandra R. Grassian, Christine Klaus, Megan Foley, Elizabeth A. Admirand, Haris Jahic, Christina Majer, Tim Wigle, Suzanne L. Jacques, Jodi Gureasko, Dorothy Brach, Trupti Lingaraj, Kip West, Sherri Smith, Nathalie Rioux, Nigel J. Waters, Cuyue Tang, Alejandra Raimondi, Michael Munchhof, James E. Mills, Scott Ribich, Margaret Porter Scott, Kevin W. Kuntz, William P. Janzen, Mikel Moyer, Jesse J. Smith, Richard Chesworth, Robert A. Copeland, P. Ann Boriack-Sjodin

published 01 Jun 2018

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Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens

Mudra Hegde, Christine Strand, Ruth E. Hanna, John G. Doench

published 25 May 2018

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An optimized electroporation approach for efficient CRISPR/Cas9 genome editing in murine zygotes

Simon E. Tröder, Lena K. Ebert, Linus Butt, Sonja Assenmacher, Bernhard Schermer, Branko Zevnik

published 03 May 2018

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One step generation of customizable gRNA vectors for multiplex CRISPR approaches through string assembly gRNA cloning (STAgR)

Christopher T. Breunig, Tamara Durovic, Andrea M. Neuner, Valentin Baumann, Maximilian F. Wiesbeck, Anna Köferle, Magdalena Götz, Jovica Ninkovic, Stefan H. Stricker

published 27 Apr 2018

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Genome comparison of different Zymomonas mobilis strains provides insights on conservation of the evolution

Chen Chen, Linfeng Wu, Qinghua Cao, Huanhuan Shao, Xuedan Li, Yizheng Zhang, Haiyan Wang, Xuemei Tan

published 25 Apr 2018

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Bifidobacteria isolated from vaginal and gut microbiomes are indistinguishable by comparative genomics

Aline C. Freitas, Janet E. Hill

published 23 Apr 2018

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Chromatin accessibility is associated with CRISPR-Cas9 efficiency in the zebrafish (Danio rerio)

Meri I. E. Uusi-Mäkelä, Harlan R. Barker, Carina A. Bäuerlein, Tomi Häkkinen, Matti Nykter, Mika Rämet

published 23 Apr 2018

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Expanding the genetic toolkit of Tribolium castaneum

Johnathan C. Rylee, Dylan J. Siniard, Kaitlin Doucette, Gabriel E. Zentner, Andrew C. Zelhof

published 12 Apr 2018

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Membrane permeabilizing amphiphilic peptide delivers recombinant transcription factor and CRISPR-Cas9/Cpf1 ribonucleoproteins in hard-to-modify cells

Thomas Del’Guidice, Jean-Pascal Lepetit-Stoffaes, Louis-Jean Bordeleau, Joannie Roberge, Vanessa Théberge, Coraline Lauvaux, Xavier Barbeau, Jessica Trottier, Vibhuti Dave, Denis-Claude Roy, Bruno Gaillet, Alain Garnier, David Guay

published 04 Apr 2018

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Genomic diversity of Taylorella equigenitalis introduced into the United States from 1978 to 2012

Jessica Hicks, Tod Stuber, Kristina Lantz, Matthew Erdman, Suelee Robbe-Austerman, Xiaoqiu Huang

published 27 Mar 2018

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