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Epigenetics

Immunohistochemical study of histone protein 3 modification in pediatric osteosarcoma identifies reduced H3K27me3 as a marker of poor treatment response

Sebastian Kondratowski, Danielle Cohen, Rebecca J. Deyell, Ash Sandhu, Jonathan W. Bush

published 21 Nov 2024

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Regulation of reactive oxygen molecules in pakchoi by histone acetylation modifications under Cd stress

Xiaoqun Cao, Ming Zhang, Xufeng Xiao, Fengrui Yin, Yuekeng Yao, Meilan Sui, Yifan Hu, Yan Xiang, Liangdeng Wang

published 20 Nov 2024

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PTEN depletion reduces H3K27me3 levels to promote epithelial-to-mesenchymal transition in epithelial colorectal cancer cells

Ahmed H. Ghobashi, Jane W. Kimani, Christopher A. Ladaika, Heather M. O’Hagan

published 19 Nov 2024

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Generation of isogenic models of Angelman syndrome and Prader-Willi syndrome in CRISPR/Cas9-engineered human embryonic stem cells

Rachel B. Gilmore, Dea Gorka, Christopher E. Stoddard, Pooja Sonawane, Justin Cotney, Stormy J. Chamberlain

published 01 Nov 2024

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iDNA-ITLM: An interpretable and transferable learning model for identifying DNA methylation

Xia Yu, Cui Yani, Zhichao Wang, Haixia Long, Rao Zeng, Xiling Liu, Bilal Anas, Jia Ren

published 31 Oct 2024

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A study of the clinical significance of mSEPT9 in monitoring recurrence and prognosis in patients with surgically treated colorectal cancer

Rong Li, Jiaojiao Chen, Xin Shen, Yanping Lin, Jiadai Tang, Guangrui Xiong, Ke Zhang, Mengying Xiang, Lin Xie, Fengdi Hu

published 28 Oct 2024

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Rabex-5 E3 and Rab5 GEF domains differ in their regulation of Ras, Notch, and PI3K signaling in Drosophila wing development

Theresa A. Reimels, Mia Steinberg, Hua Yan, Sivan Shahar, Ashley Rosenberg, Kristina Kalafsky, Max Luf, Lindsay Kelly, Stacia Octaviani, Cathie M. Pfleger

published 28 Oct 2024

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Six3 and Six6 jointly control diverse target genes in multiple cell populations over developmental trajectories of mouse embryonic retinal progenitor cells

Alexander Ferrena, Xusheng Zhang, Rupendra Shrestha, Deyou Zheng, Wei Liu

published 24 Oct 2024

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Sprayable RNAi for silencing of important genes to manage red palm weevil, Rhynchophorus ferrugineus (Coleoptera: Curculionidae)

Muhammad Naeem Sattar, Muhammad Nadir Naqqash, Adel A. Rezk, Khalid Mehmood, Allah Bakhsh, Hamadttu Elshafie, Jameel M. Al-Khayri

published 24 Oct 2024

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Epigenetic aging differentially impacts breast cancer risk by self-reported race

Yanning Wu, Megan E. Miller, Hannah L. Gilmore, Cheryl L. Thompson, Fredrick R. Schumacher

published 24 Oct 2024

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Voluntary wheel running exercise rescues behaviorally-evoked acetylcholine efflux in the medial prefrontal cortex and epigenetic changes in ChAT genes following adolescent intermittent ethanol exposure

Matthew J. Fecik, Polliana T. Nunes, Ryan P. Vetreno, Lisa M. Savage

published 22 Oct 2024

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Isoginkgetin and Madrasin are poor splicing inhibitors

Michael Tellier, Gilbert Ansa, Shona Murphy

published 21 Oct 2024

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Enhanced thermal stability enables human mismatch-specific thymine–DNA glycosylase to catalyse futile DNA repair

Diana Manapkyzy, Botagoz Joldybayeva, Alexander A. Ishchenko, Bakhyt T. Matkarimov, Dmitry O. Zharkov, Sabira Taipakova, Murat K. Saparbaev

published 18 Oct 2024

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