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Endosomes

A type 2 diabetes disease module with a high collective influence for Cdk2 and PTPLAD1 is localized in endosomes

Martial Boutchueng-Djidjou, Pascal Belleau, Nicolas Bilodeau, Suzanne Fortier, Sylvie Bourassa, Arnaud Droit, Sabine Elowe, Robert L. Faure

published 09 Oct 2018

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Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P₂ but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation

Diego Sbrissa, Ghassan Naisan, Ognian C. Ikonomov, Assia Shisheva

published 21 Sep 2018

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Reinterpretation of the localization of the ATP binding cassette transporter ABCG1 in insulin-secreting cells and insights regarding its trafficking and function

Megan T. Harris, Syed Saad Hussain, Candice M. Inouye, Anna M. Castle, J. David Castle

published 20 Sep 2018

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TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes

Nobumasa Takasugi, Runa Araya, Yuji Kamikubo, Nanaka Kaneshiro, Ryosuke Imaoka, Hao Jin, Taku Kashiyama, Yoshie Hashimoto, Masaru Kurosawa, Takashi Uehara, Nobuyuki Nukina, Takashi Sakurai

published 07 Aug 2018

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Tyrosine 870 of TLR9 is critical for receptor maturation rather than phosphorylation-dependent ligand-induced signaling

Chhanda Biswas, Sheila Rao, Katharine Slade, David Hyman, Devin Dersh, Adriana R. Mantegazza, Philip W. Zoltick, Michael S. Marks, Yair Argon, Edward M. Behrens

published 19 Jul 2018

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SIMPLE binds specifically to PI4P through SIMPLE-like domain and participates in protein trafficking in the trans-Golgi network and/or recycling endosomes

Yasuhiro Moriwaki, Yuho Ohno, Tomohiro Ishii, Yuki Takamura, Yuko Kita, Kazuhiko Watabe, Kazunori Sango, Shoutaro Tsuji, Hidemi Misawa

published 28 Jun 2018

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The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in mammalian cells

Krishna Chintaluri, Brady D. Goulden, Camilyn Celmenza, Golam Saffi, Emily Miraglia, Gerald R. V. Hammond, Roberto J. Botelho

published 05 Jun 2018

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Plasma membrane insertion of KCa2.3 (SK3) is dependent upon the SNARE proteins, syntaxin-4 and SNAP23

Claudia A. Bertuccio, Tony T. Wang, Kirk L. Hamilton, Diego J. Rodriguez-Gil, Steven B. Condliffe, Daniel C. Devor

published 16 May 2018

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Design and preclinical characterization of ALXN1210: A novel anti-C5 antibody with extended duration of action

Douglas Sheridan, Zhao-Xue Yu, Yuchun Zhang, Rekha Patel, Fang Sun, Melissa A. Lasaro, Keith Bouchard, Bruce Andrien, Andre Marozsan, Yi Wang, Paul Tamburini

published 12 Apr 2018

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Inducing cell death in vitro in cancer cells by targeted delivery of cytochrome c via a transferrin conjugate

Manoj Saxena, Yamixa Delgado, Rohit Kumar Sharma, Shweta Sharma, Solimar Liz Ponce De León Guzmán, Arthur D. Tinoco, Kai Griebenow

published 12 Apr 2018

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Mutations in EEA1 are associated with allergic bronchopulmonary aspergillosis and affect phagocytosis of Aspergillus fumigatus by human macrophages

Nicola L. D. Overton, Axel A. Brakhage, Andreas Thywißen, David W. Denning, Paul Bowyer

published 16 Mar 2018

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The cellular uptake of angiogenin, an angiogenic and neurotrophic factor is through multiple pathways and largely dynamin independent

Ross Ferguson, Vasanta Subramanian

published 27 Feb 2018

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Drosophila VAMP7 regulates Wingless intracellular trafficking

Han Gao, Fang He, Xinhua Lin, Yihui Wu

published 24 Oct 2017

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