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Dose prediction methods

Physiologically-Based Toxicokinetic Modeling of Zearalenone and Its Metabolites: Application to the Jersey Girl Study

Dwaipayan Mukherjee, Steven G. Royce, Jocelyn A. Alexander, Brian Buckley, Sastry S. Isukapalli, Elisa V. Bandera, Helmut Zarbl, Panos G. Georgopoulos

published 04 Dec 2014

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A Semi-Physiologically Based Pharmacokinetic Pharmacodynamic Model for Glycyrrhizin-Induced Pseudoaldosteronism and Prediction of the Dose Limit Causing Hypokalemia in a Virtual Elderly Population

Ruijuan Xu, Xiaoquan Liu, Jin Yang

published 02 Dec 2014

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A Phase 1 Study of ¹³¹I-CLR1404 in Patients with Relapsed or Refractory Advanced Solid Tumors: Dosimetry, Biodistribution, Pharmacokinetics, and Safety

Joseph J. Grudzinski, Benjamin Titz, Kevin Kozak, William Clarke, Ernest Allen, LisaAnn Trembath, Michael Stabin, John Marshall, Steve Y. Cho, Terence Z. Wong, Joanne Mortimer, Jamey P. Weichert

published 17 Nov 2014

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Synergistic Effect of High Charge and Energy Particle Radiation and Chronological Age on Biomarkers of Oxidative Stress and Tissue Degeneration: A Ground-Based Study Using the Vertebrate Laboratory Model Organism Oryzias latipes

Xuan Zheng, Xinyan Zhang, Lingling Ding, Jeffrey R. Lee, Paul M. Weinberger, William S. Dynan

published 06 Nov 2014

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Impact of the Superoxide Dismutase 2 Val16Ala Polymorphism on the Relationship between Valproic Acid Exposure and Elevation of γ-Glutamyltransferase in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis

Naoki Ogusu, Junji Saruwatari, Hiroo Nakashima, Madoka Noai, Miki Nishimura, Mariko Deguchi, Kentaro Oniki, Norio Yasui-Furukori, Sunao Kaneko, Takateru Ishitsu, Kazuko Nakagaswa

published 05 Nov 2014

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Quantitative and Qualitative Assessment of Yttrium-90 PET/CT Imaging

Ali Asgar Attarwala, Flavia Molina-Duran, Karen-Anett Büsing, Stefan O. Schönberg, Dale L. Bailey, Kathy Willowson, Gerhard Glatting

published 04 Nov 2014

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Complication Probability Models for Radiation-Induced Heart Valvular Dysfunction: Do Heart-Lung Interactions Play a Role?

Laura Cella, Giuseppe Palma, Joseph O. Deasy, Jung Hun Oh, Raffaele Liuzzi, Vittoria D’Avino, Manuel Conson, Novella Pugliese, Marco Picardi, Marco Salvatore, Roberto Pacelli

published 31 Oct 2014

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Dose Schedule Optimization and the Pharmacokinetic Driver of Neutropenia

Mayankbhai Patel, Santhosh Palani, Arijit Chakravarty, Johnny Yang, Wen Chyi Shyu, Jerome T. Mettetal

published 31 Oct 2014

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Correlation between Compartmental Tenofovir Concentrations and an Ex Vivo Rectal Biopsy Model of Tissue Infectibility in the RMP-02/MTN-006 Phase 1 Study

Nicola Richardson-Harman, Craig W. Hendrix, Namandjé N. Bumpus, Christine Mauck, Ross D. Cranston, Kuo Yang, Julie Elliott, Karen Tanner, Ian McGowan, Angela Kashuba, Peter A. Anton

published 28 Oct 2014

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A Multi-Compartment Single and Multiple Dose Pharmacokinetic Comparison of Rectally Applied Tenofovir 1% Gel and Oral Tenofovir Disoproxil Fumarate

Kuo-Hsiung Yang, Craig Hendrix, Namandje Bumpus, Julie Elliott, Karen Tanner, Christine Mauck, Ross Cranston, Ian McGowan, Nicola Richardson-Harman, Peter A. Anton, Angela D. M. Kashuba

published 28 Oct 2014

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A Closed Parameterization of DNA–Damage by Charged Particles, as a Function of Energy — A Geometrical Approach

Frank Van den Heuvel

published 23 Oct 2014

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Optimal Chemotherapy for Leukemia: A Model-Based Strategy for Individualized Treatment

Devaraj Jayachandran, Ann E. Rundell, Robert E. Hannemann, Terry A. Vik, Doraiswami Ramkrishna

published 13 Oct 2014

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Clinical Validation and Implications of Dried Blood Spot Sampling of Carbamazepine, Valproic Acid and Phenytoin in Patients with Epilepsy

Sing Teang Kong, Shih-Hui Lim, Wee Beng Lee, Pasikanthi Kishore Kumar, Hwee Yi Stella Wang, Yan Lam Shannon Ng, Pei Shieen Wong, Paul C. Ho

published 25 Sep 2014

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