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Crystal structure

Creating Novel Activated Factor XI Inhibitors through Fragment Based Lead Generation and Structure Aided Drug Design

Ola Fjellström, Sibel Akkaya, Hans-Georg Beisel, Per-Olof Eriksson, Karl Erixon, David Gustafsson, Ulrik Jurva, Daiwu Kang, David Karis, Wolfgang Knecht, Viveca Nerme, Ingemar Nilsson, Thomas Olsson, Alma Redzic, Robert Roth, Jenny Sandmark, Anna Tigerström, Linda Öster

published 28 Jan 2015

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Structure of the SthK Carboxy-Terminal Region Reveals a Gating Mechanism for Cyclic Nucleotide-Modulated Ion Channels

Divya Kesters, Marijke Brams, Mieke Nys, Eveline Wijckmans, Radovan Spurny, Thomas Voets, Jan Tytgat, Jana Kusch, Chris Ulens

published 27 Jan 2015

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Six Amino Acid Residues in a 1200 Å2 Interface Mediate Binding of Factor VIII to an IgG4κ Inhibitory Antibody

Jasper C. Lin, Ruth A. Ettinger, Jason T. Schuman, Ai-Hong Zhang, Muhammad Wamiq-Adhami, Phuong-Cac T. Nguyen, Shelley M. Nakaya-Fletcher, Komal Puranik, Arthur R. Thompson, Kathleen P. Pratt

published 23 Jan 2015

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Time-Dependent Subcellular Distribution and Effects of Carbon Nanotubes in Lungs of Mice

Carsten Købler, Sarah S. Poulsen, Anne T. Saber, Nicklas R. Jacobsen, Håkan Wallin, Carole L. Yauk, Sabina Halappanavar, Ulla Vogel, Klaus Qvortrup, Kristian Mølhave

published 23 Jan 2015

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Computational Analysis and Low-Scale Constitutive Expression of Laccases Synthetic Genes GlLCC1 from Ganoderma lucidum and POXA 1B from Pleurotus ostreatus in Pichia pastoris

Claudia M. Rivera-Hoyos, Edwin David Morales-Álvarez, Sergio Alejandro Poveda-Cuevas, Edwin Alfredo Reyes-Guzmán, Raúl A. Poutou-Piñales, Edgar Antonio Reyes-Montaño, Aura Marina Pedroza-Rodríguez, Refugio Rodríguez-Vázquez, Ángela M. Cardozo-Bernal

published 22 Jan 2015

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Characterisation of Calcium Phosphate Crystals on Calcified Human Aortic Vascular Smooth Muscle Cells and Potential Role of Magnesium

Loïc Louvet, Dominique Bazin, Janine Büchel, Sonja Steppan, Jutta Passlick-Deetjen, Ziad A. Massy

published 21 Jan 2015

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The Human Otubain2-Ubiquitin Structure Provides Insights into the Cleavage Specificity of Poly-Ubiquitin-Linkages

Mikael Altun, Thomas S. Walter, Holger B. Kramer, Patrick Herr, Alexander Iphöfer, Johan Boström, Yael David, Alia Komsany, Nicola Ternette, Ami Navon, David I. Stuart, Jingshan Ren, Benedikt M. Kessler

published 15 Jan 2015

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A Cytosolic Juxtamembrane Interface Modulates Plexin A3 Oligomerization and Signal Transduction

Rachael Barton, Danica Palacio, M. Kathryn Iovine, Bryan W. Berger

published 07 Jan 2015

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Distinct Regions of the Large Extracellular Domain of Tetraspanin CD9 Are Involved in the Control of Human Multinucleated Giant Cell Formation

Rachel S. Hulme, Adrian Higginbottom, John Palmer, Lynda J. Partridge, Peter N. Monk

published 31 Dec 2014

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Functional Mapping of Protein-Protein Interactions in an Enzyme Complex by Directed Evolution

Kathrin Roderer, Martin Neuenschwander, Giosiana Codoni, Severin Sasso, Marianne Gamper, Peter Kast

published 31 Dec 2014

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On the Modularity of the Intrinsic Flexibility of the µ Opioid Receptor: A Computational Study

Mathieu Fossépré, Laurence Leherte, Aatto Laaksonen, Daniel P. Vercauteren

published 30 Dec 2014

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Structure Based Annotation of Helicobacter pylori Strain 26695 Proteome

Swati Singh, Praveen Kumar Guttula, Lalitha Guruprasad

published 30 Dec 2014

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A Cyclic Peptidic Serine Protease Inhibitor: Increasing Affinity by Increasing Peptide Flexibility

Baoyu Zhao, Peng Xu, Longguang Jiang, Berit Paaske, Tobias Kromann-Hansen, Jan K. Jensen, Hans Peter Sørensen, Zhuo Liu, Jakob T. Nielsen, Anni Christensen, Masood Hosseini, Kasper K. Sørensen, Niels Christian Nielsen, Knud J. Jensen, Mingdong Huang, Peter A. Andreasen

published 29 Dec 2014

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