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Computer-aided drug design

Rare, potentially pathogenic variants in 21 keratoconus candidate genes are not enriched in cases in a large Australian cohort of European descent

Sionne E. M. Lucas, Tiger Zhou, Nicholas B. Blackburn, Richard A. Mills, Jonathan Ellis, Paul Leo, Emmanuelle Souzeau, Bronwyn Ridge, Jac C. Charlesworth, Richard Lindsay, Jamie E. Craig, Kathryn P. Burdon

published 20 Jun 2018

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Generalising better: Applying deep learning to integrate deleteriousness prediction scores for whole-exome SNV studies

Ilia Korvigo, Andrey Afanasyev, Nikolay Romashchenko, Mikhail Skoblov

published 14 Mar 2018

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Overall survival in EGFR mutated non-small-cell lung cancer patients treated with afatinib after EGFR TKI and resistant mechanisms upon disease progression

A. J. van der Wekken, J. L. Kuiper, A. Saber, M. M. Terpstra, J. Wei, T. J. N. Hiltermann, E. Thunnissen, D. A. M. Heideman, W. Timens, E. Schuuring, K. Kok, E. F. Smit, A. van den Berg, H. J. M. Groen

published 30 Aug 2017

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Whole gene sequencing identifies deep-intronic variants with potential functional impact in patients with hypertrophic cardiomyopathy

Rita Mendes de Almeida, Joana Tavares, Sandra Martins, Teresa Carvalho, Francisco J. Enguita, Dulce Brito, Maria Carmo-Fonseca, Luís Rocha Lopes

published 10 Aug 2017

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Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy

Ulrike Esslinger, Sophie Garnier, Agathe Korniat, Carole Proust, Georgios Kararigas, Martina Müller-Nurasyid, Jean-Philippe Empana, Michael P. Morley, Claire Perret, Klaus Stark, Alexander G. Bick, Sanjay K. Prasad, Jennifer Kriebel, Jin Li, Laurence Tiret, Konstantin Strauch, Declan P. O'Regan, Kenneth B. Marguiles, Jonathan G. Seidman, Pierre Boutouyrie, Patrick Lacolley, Xavier Jouven, Christian Hengstenberg, Michel Komajda, Hakon Hakonarson, Richard Isnard, Eloisa Arbustini, Harald Grallert, Stuart A. Cook, Christine E. Seidman, Vera Regitz-Zagrosek, Thomas P. Cappola, Philippe Charron, François Cambien, Eric Villard

published 15 Mar 2017

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Incorporating Non-Coding Annotations into Rare Variant Analysis

Tom G. Richardson, Colin Campbell, Nicholas J Timpson, Tom R. Gaunt

published 29 Apr 2016

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A Protein Domain and Family Based Approach to Rare Variant Association Analysis

Tom G. Richardson, Hashem A. Shihab, Manuel A. Rivas, Mark I. McCarthy, Colin Campbell, Nicholas J. Timpson, Tom R. Gaunt

published 29 Apr 2016

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In-Silico Analysis of Inflammatory Bowel Disease (IBD) GWAS Loci to Novel Connections

Md. Mesbah-Uddin, Ramu Elango, Babajan Banaganapalli, Noor Ahmad Shaik, Fahad A. Al-Abbasi

published 18 Mar 2015

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Evidence for Evolutionary and Nonevolutionary Forces Shaping the Distribution of Human Genetic Variants near Transcription Start Sites

Giovanni Scala, Ornella Affinito, Gennaro Miele, Antonella Monticelli, Sergio Cocozza

published 04 Dec 2014

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Harnessing Gene Expression Networks to Prioritize Candidate Epileptic Encephalopathy Genes

Karen L. Oliver, Vesna Lukic, Natalie P. Thorne, Samuel F. Berkovic, Ingrid E. Scheffer, Melanie Bahlo

published 09 Jul 2014

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Inhibition of Histo-blood Group Antigen Binding as a Novel Strategy to Block Norovirus Infections

Xu-Fu Zhang, Ming Tan, Monica Chhabra, Ying-Chun Dai, Jarek Meller, Xi Jiang

published 19 Jul 2013

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TCM Database@Taiwan: The World's Largest Traditional Chinese Medicine Database for Drug Screening In Silico

Calvin Yu-Chian Chen

published 06 Jan 2011

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