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Computer-aided drug design

Rare, potentially pathogenic variants in 21 keratoconus candidate genes are not enriched in cases in a large Australian cohort of European descent

Sionne E. M. Lucas, Tiger Zhou, [ ... ], Kathryn P. Burdon

Generalising better: Applying deep learning to integrate deleteriousness prediction scores for whole-exome SNV studies

Ilia Korvigo, Andrey Afanasyev, Nikolay Romashchenko, Mikhail Skoblov

Overall survival in EGFR mutated non-small-cell lung cancer patients treated with afatinib after EGFR TKI and resistant mechanisms upon disease progression

A. J. van der Wekken, J. L. Kuiper, [ ... ], H. J. M. Groen

Whole gene sequencing identifies deep-intronic variants with potential functional impact in patients with hypertrophic cardiomyopathy

Rita Mendes de Almeida, Joana Tavares, [ ... ], Luís Rocha Lopes

Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy

Ulrike Esslinger, Sophie Garnier, [ ... ], Eric Villard

Incorporating Non-Coding Annotations into Rare Variant Analysis

Tom G. Richardson, Colin Campbell, Nicholas J Timpson, Tom R. Gaunt

A Protein Domain and Family Based Approach to Rare Variant Association Analysis

Tom G. Richardson, Hashem A. Shihab, [ ... ], Tom R. Gaunt

In-Silico Analysis of Inflammatory Bowel Disease (IBD) GWAS Loci to Novel Connections

Md. Mesbah-Uddin, Ramu Elango, [ ... ], Fahad A. Al-Abbasi

Evidence for Evolutionary and Nonevolutionary Forces Shaping the Distribution of Human Genetic Variants near Transcription Start Sites

Giovanni Scala, Ornella Affinito, [ ... ], Sergio Cocozza

Harnessing Gene Expression Networks to Prioritize Candidate Epileptic Encephalopathy Genes

Karen L. Oliver, Vesna Lukic, [ ... ], Melanie Bahlo

Inhibition of Histo-blood Group Antigen Binding as a Novel Strategy to Block Norovirus Infections

Xu-Fu Zhang, Ming Tan, [ ... ], Xi Jiang

TCM Database@Taiwan: The World's Largest Traditional Chinese Medicine Database for Drug Screening In Silico

Calvin Yu-Chian Chen

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