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Complement activation

A computational model for the evaluation of complement system regulation under homeostasis, disease, and drug intervention

Nehemiah Zewde, Dimitrios Morikis

published 06 Jun 2018

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In vitro generation and bioactivity evaluation of C-reactive protein intermediate

Jian-Min Lv, Ming-Yu Wang

published 31 May 2018

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A monoclonal antibody targeting amyloid β (Aβ) restores complement factor I bioactivity: Potential implications in age-related macular degeneration and Alzheimer’s disease

Kameran Lashkari, Gianna Teague, Hong Chen, Yong-Qing Lin, Sanjay Kumar, Megan M. McLaughlin, Francisco J. López

published 21 May 2018

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Changes in N-glycans of IgG4 and its relationship with the existence of hypocomplementemia and individual organ involvement in patients with IgG4-related disease

Naoki Konno, Mitsuru Sugimoto, Tadayuki Takagi, Makiko Furuya, Tomoyuki Asano, Shuzo Sato, Hiroko Kobayashi, Kiyoshi Migita, Yoshiaki Miura, Taichi Aihara, Atsushi Komatsuda, Hiromasa Ohira, Hiroshi Watanabe

published 19 Apr 2018

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Design and preclinical characterization of ALXN1210: A novel anti-C5 antibody with extended duration of action

Douglas Sheridan, Zhao-Xue Yu, Yuchun Zhang, Rekha Patel, Fang Sun, Melissa A. Lasaro, Keith Bouchard, Bruce Andrien, Andre Marozsan, Yi Wang, Paul Tamburini

published 12 Apr 2018

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Dimeric IgG complexes from IVIg are incapable of inducing in vitro neutrophil degranulation or complement activation

Iwan Kustiawan, Ninotska I. L. Derksen, Theresa Guhr, Simone Kruithof, Wim Jiskoot, Gestur Vidarsson, Theo Rispens

published 10 Apr 2018

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Hypocomplementemia is associated with worse renal survival in ANCA-positive granulomatosis with polyangiitis and microscopic polyangiitis

Samuel Deshayes, Achille Aouba, Kathy Khoy, Delphine Mariotte, Thierry Lobbedez, Nicolas Martin Silva

published 05 Apr 2018

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The use of the vaccinia virus complement control protein (VCP) in the rat retina

Nilisha Fernando, Riccardo Natoli, Tanja Racic, Yvette Wooff, Jan Provis, Krisztina Valter

published 13 Mar 2018

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The role of complement activation in rhabdomyolysis-induced acute kidney injury

XuDong Huang, Wei Zhao, LiXia Zhang, XinJun Yang, LiHui Wang, YunShuang Chen, JingHua Wang, Chao Zhang, GuangLi Wu

published 21 Feb 2018

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Hexons from adenovirus serotypes 5 and 48 differentially protect adenovirus vectors from neutralization by mouse and human serum

Andrew W. Harmon, Rituparna Moitra, Zhili Xu, Andrew P. Byrnes

published 05 Feb 2018

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MASP-1 of the complement system enhances clot formation in a microvascular whole blood flow model

Lorenz Jenny, József Dobó, Péter Gál, Gábor Pál, Wilbur A. Lam, Verena Schroeder

published 11 Jan 2018

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Reduced order modeling and analysis of the human complement system

Adithya Sagar, Wei Dai, Mason Minot, Rachel LeCover, Jeffrey D. Varner

published 20 Nov 2017

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Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice

Ingrid Stroo, Jack Yang, Adam A. Anas, J. Daan de Boer, Gerard van Mierlo, Dorina Roem, Diana Wouters, Ruchira Engel, Joris J. T. H. Roelofs, Cornelis van ‘t Veer, Tom van der Poll, Sacha Zeerleder

published 16 Oct 2017

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