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CHO cells

Impact of Diverse Immune Evasion Mechanisms of Cancer Cells on T Cells Engaged by EpCAM/CD3-Bispecific Antibody Construct AMG 110

Wibke Deisting, Tobias Raum, Peter Kufer, Patrick A. Baeuerle, Markus Münz

published 28 Oct 2015

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Designed Amino Acid Feed in Improvement of Production and Quality Targets of a Therapeutic Monoclonal Antibody

Fatemeh Torkashvand, Behrouz Vaziri, Shayan Maleknia, Amir Heydari, Manouchehr Vossoughi, Fatemeh Davami, Fereidoun Mahboudi

published 19 Oct 2015

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High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation

Masato Maesako, Maiko Uemura, Yoshitaka Tashiro, Kazuki Sasaki, Kiwamu Watanabe, Yasuha Noda, Karin Ueda, Megumi Asada-Utsugi, Masakazu Kubota, Katsuya Okawa, Masafumi Ihara, Shun Shimohama, Kengo Uemura, Ayae Kinoshita

published 28 Sep 2015

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CD44 Binding to Hyaluronic Acid Is Redox Regulated by a Labile Disulfide Bond in the Hyaluronic Acid Binding Site

Helena Kellett-Clarke, Monika Stegmann, A. Neil Barclay, Clive Metcalfe

published 17 Sep 2015

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A Single Dynamic Metabolic Model Can Describe mAb Producing CHO Cell Batch and Fed-Batch Cultures on Different Culture Media

Julien Robitaille, Jingkui Chen, Mario Jolicoeur

published 02 Sep 2015

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Inhibition of αIIbβ3 Ligand Binding by an αIIb Peptide that Clasps the Hybrid Domain to the βI Domain of β3

Wen Hwa Lee, Elisabeth Schaffner-Reckinger, Demokritos C. Tsoukatos, Kelly Aylward, Vassilios Moussis, Vassilios Tsikaris, Paraskevi Trypou, Marion Egot, Dominique Baruch, Nelly Kieffer, Christilla Bachelot-Loza

published 02 Sep 2015

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The Human Acid-Sensing Ion Channel ASIC1a: Evidence for a Homotetrameric Assembly State at the Cell Surface

Miguel Xavier van Bemmelen, Delphine Huser, Ivan Gautschi, Laurent Schild

published 07 Aug 2015

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Glycoengineered Monoclonal Antibodies with Homogeneous Glycan (M3, G0, G2, and A2) Using a Chemoenzymatic Approach Have Different Affinities for FcγRIIIa and Variable Antibody-Dependent Cellular Cytotoxicity Activities

Masaki Kurogochi, Masako Mori, Kenji Osumi, Mami Tojino, Shu-ichi Sugawara, Shou Takashima, Yuriko Hirose, Wataru Tsukimura, Mamoru Mizuno, Junko Amano, Akio Matsuda, Masahiro Tomita, Atsushi Takayanagi, Shin-Ichiro Shoda, Takashi Shirai

published 22 Jul 2015

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αPIX Is a Trafficking Regulator that Balances Recycling and Degradation of the Epidermal Growth Factor Receptor

Fanny Kortüm, Frederike Leonie Harms, Natascha Hennighausen, Georg Rosenberger

published 15 Jul 2015

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Regulation of Pro-Apoptotic Phosphorylation of Kv2.1 K⁺ Channels

Kai He, Meghan C. McCord, Karen A. Hartnett, Elias Aizenman

published 26 Jun 2015

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Identification and Characterization of Xlr5c as a Novel Nuclear Localization Protein in Mouse Germ Cells

Xin-Jie Zhuang, Wen-hao Tang, Chang-yu Liu, Jin-liang Zhu, Xue Feng, Jie Yan, Ying Lian, Ping Liu, Jie Qiao

published 15 Jun 2015

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The Identification of Novel Protein-Protein Interactions in Liver that Affect Glucagon Receptor Activity

Junfeng Han, Ming Zhang, Sean Froese, Feihan F. Dai, Mélanie Robitaille, Alpana Bhattacharjee, Xinyi Huang, Weiping Jia, Stéphane Angers, Michael B. Wheeler, Li Wei

published 15 Jun 2015

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Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses

Ayaka Tobo, Masayuki Tobo, Takashi Nakakura, Masashi Ebara, Hideaki Tomura, Chihiro Mogi, Dong-Soon Im, Naoya Murata, Atsushi Kuwabara, Saki Ito, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto, Michio Nakaya, Hitoshi Kurose, Koichi Sato, Fumikazu Okajima

published 12 Jun 2015

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