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Cell lines

Amino acid residues 655 and 969 in the spike protein of Omicron subvariant BA.1 control use of TMPRSS2 versus Cathepsin L dependent entry pathways and cell tropism

Cheila Rocha, Prerna Arora, Lu Zhang, Anzhalika Sidarovich, Luise Graichen, Anna-Sophie Moldenhauer, Stefan Pöhlmann, Markus Hoffmann

published 14 Aug 2025

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Identification of glutathione transferase (GST P1) inhibitors via a high-throughput screening assay and implications as alternative treatment options for breast cancers

Sarah A. P. Pereira, Jonathan Vesin, Marc Chambon, Gerardo Turcatti, M. Lúcia M. F. S. Saraiva, Paul J. Dyson

published 24 Jul 2025

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Impact of mtG3PDH inhibitors on proliferation and metabolism of androgen receptor-negative prostate cancer cells: Role of extracellular pyruvate

Floriana Jessica Di Paola, Luiza HD Cardoso, Efterpi Nikitopoulou, Bianca Kulik, Sandra Rühl, Alexander Eva, Natascha Sommer, Thomas Linn, Erich Gnaiger, Klaus Failing, Kathrin Büttner, Christian Frezza, Sybille Mazurek

published 09 Jun 2025

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Thionated levofloxacin derivative: Potential repurposing for cancer treatment and synergism with doxorubicin on doxorubicin-resistant lung cancer cells

Hamza Abumansour, Osama H. Abusara, Mohammad Abu-Sini, Wiam Khalil, Ali I. M. Ibrahim, Amal M. Badawoud, Majed S. Al Yami, Dina H. Abulebdah, Shiraz Halloush

published 09 Jun 2025

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The tumor suppressor FAT1 controls YAP/TAZ protein degradation and tumor cell proliferation through E3 ligase MIB2

Rui Li, Boris Strilic, Young-June Jin, Jingchen Shao, Yundong Peng, Lei Wang, Qi Quan, Zhiyong Wang, Johannes Graumann, J. Silvio Gutkind, Nina Wettschureck, Stefan Offermanns

published 06 Jun 2025

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Screening and validation of 3’-Methoxydaidzein as a therapeutic agent in ulcerative colitis based on disulfidptosis-associated molecular clusters

Jie Yuan, Chongyong Gao, Wang Xin, Fanlin Meng, Hong Zhang

published 06 Jun 2025

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Computational investigation and experimental validation of the molecular mechanism of Solanecio mannii aqueous roots extract against cervical cancer

Amel Elbasyouni, Mutinda C. Kyama, Hany A. El-Shemy, Peter G. Mwitari

published 30 May 2025

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Heat shock transcription factor 2 reduces mitochondrial pathway apoptosis in intestinal epithelial cells by inhibiting the increase in mitochondrial membrane permeability in ulcerative colitis

Wen Wang, Yunling Wen, Juan Luo, Yinglei Miao, Fengrui Zhang, Junkun Niu

published 29 May 2025

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Two cancer cell lines utilize Myosin 10 and the kinesin HSET differentially to maintain mitotic spindle bipolarity

Yang-In Yim, Xufeng Wu, Anjelika Gasilina, John A. Hammer

published 29 May 2025

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Reducing the effective dosage of flutamide on prostate cancer cell lines through combination with selenium nanoparticles: An in-vitro study

Iman Menbari Oskouie, Fatemeh Khatami, Amin Shiralizadeh Dezfuli, Rahil Mashhadi, Akram Mirzaei, Seyedeh Negin Hashemi Dougaheh, Helia Azodian Ghajar, Ramin Heshmat, Seyed Mohammad Kazem Aghamir

published 19 May 2025

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LncRNA NEAT1 protects uremic toxin-induced intestinal epithelial barrier injury by regulating miR-122-5p/Occludin axis

Meng Han, Pathuama P, Jinhai Tian, Chen Wang, Shengnan Zhou, Lina Fu, Libin Wang, Na Tian

published 08 May 2025

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Is laccase from medicinal mushroom Cerrena unicolor cytotoxic to colon cancer cell line CT-26?

Daria Sondej, Dominika Pigoń-Zając, Magdalena Jaszek, Dawid Stefaniuk, Anna Matuszewska, Kamil Bielak, Grzegorz Opielak, Teresa Małecka-Massalska, Mansur Rahnama-Hezavah, Monika Prendecka-Wróbel

published 08 May 2025

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The plant matrix of Artemisia annua L. for the treatment of malaria: Pharmacodynamic and pharmacokinetic studies

Fujie Xu, Xiaohang Shan, Jialin Li, Jing Li, Jiqiao Yuan, Daozeng Zou, Manyuan Wang

published 07 May 2025

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