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Cell binding assay

Whole egg consumption increases gene expression within the glutathione pathway in the liver of Zucker Diabetic Fatty rats

Joe L. Webb, Amanda E. Bries, Brooke Vogel, Claudia Carrillo, Lily Harvison, Timothy A. Day, Michael J. Kimber, Rudy J. Valentine, Matthew J. Rowling, Stephanie Clark, Elizabeth M. McNeill, Kevin L. Schalinske

published 03 Nov 2020

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Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms

Beatrice Cameron, Tarik Dabdoubi, Laurence Berthou-Soulié, Marie Gagnaire, Isabelle Arnould, Anne Severac, Fabienne Soubrier, Jacqueline Morales, Philip A. Leighton, William Harriman, Kathryn Ching, Yasmina Abdiche, Katarina Radošević, Thomas Bouquin

published 16 Jul 2020

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An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications

Yihui Shi, Walter Bray, Alexander J. Smith, Wei Zhou, Joy Calaoagan, Chandraiah Lagisetti, Lidia Sambucetti, Phillip Crews, R. Scott Lokey, Thomas R. Webb

published 29 May 2020

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A homogeneous SIRPα-CD47 cell-based, ligand-binding assay: Utility for small molecule drug development in immuno-oncology

Teresa L. Burgess, Joshua D. Amason, Jeffrey S. Rubin, Damien Y. Duveau, Laurence Lamy, David D. Roberts, Catherine L. Farrell, James Inglese, Craig J. Thomas, Thomas W. Miller

published 02 Apr 2020

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Brain Shuttle Neprilysin reduces central Amyloid-β levels

Christopher R. Campos, Alicia M. Kemble, Jens Niewoehner, Per-Ola Freskgård, Eduard Urich

published 10 Mar 2020

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Assessing the binding properties of the anti-PD-1 antibody landscape using label-free biosensors

Michael E. Brown, Daniel Bedinger, Asparouh Lilov, Palaniswami Rathanaswami, Maximiliano Vásquez, Stéphanie Durand, Ian Wallace-Moyer, Lihui Zhong, Juergen H. Nett, Irina Burnina, Isabelle Caffry, Heather Lynaugh, Melanie Sinclair, Tingwan Sun, John Bukowski, Yingda Xu, Yasmina Noubia Abdiche

published 05 Mar 2020

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A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans

Sarah A. Pendergrass, Steven Buyske, Janina M. Jeff, Alex Frase, Scott Dudek, Yuki Bradford, Jose-Luis Ambite, Christy L. Avery, Petra Buzkova, Ewa Deelman, Megan D. Fesinmeyer, Christopher Haiman, Gerardo Heiss, Lucia A. Hindorff, Chun-Nan Hsu, Rebecca D. Jackson, Yi Lin, Loic Le Marchand, Tara C. Matise, Kristine R. Monroe, Larry Moreland, Kari E. North, Sungshim L. Park, Alex Reiner, Robert Wallace, Lynne R. Wilkens, Charles Kooperberg, Marylyn D. Ritchie, Dana C. Crawford

published 31 Dec 2019

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Binding and functional profiling of antibody mutants guides selection of optimal candidates as antibody drug conjugates

John C. Zwaagstra, Traian Sulea, Jason Baardsnes, Stevo Radinovic, Yuneivy Cepero-Donates, Alma Robert, Maureen D. O’Connor-McCourt, Ilia A. Tikhomirov, Maria Luz. Jaramillo

published 31 Dec 2019

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Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids

Qin Huang, Ken Y. Chan, Isabelle G. Tobey, Yujia Alina Chan, Tim Poterba, Christine L. Boutros, Alejandro B. Balazs, Richard Daneman, Jonathan M. Bloom, Cotton Seed, Benjamin E. Deverman

published 14 Nov 2019

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Gene expression profiling of whole blood: A comparative assessment of RNA-stabilizing collection methods

Duncan E. Donohue, Aarti Gautam, Stacy-Ann Miller, Seshamalini Srinivasan, Duna Abu-Amara, Ross Campbell, Charles R. Marmar, Rasha Hammamieh, Marti Jett

published 10 Oct 2019

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Heat shock-induced chaperoning by Hsp70 is enabled in-cell

Drishti Guin, Hannah Gelman, Yuhan Wang, Martin Gruebele

published 26 Sep 2019

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Progranulin deficiency leads to reduced glucocerebrosidase activity

Xiaolai Zhou, Daniel H. Paushter, Mitchell D. Pagan, Dongsung Kim, Mariela Nunez Santos, Raquel L. Lieberman, Herman S. Overkleeft, Ying Sun, Marcus B. Smolka, Fenghua Hu

published 10 Jul 2019

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Human antibody repertoire frequently includes antibodies to a bacterial biofilm associated protein

Stefan Ryser, Edgar Tenorio, Angeles Estellés, Lawrence M. Kauvar

published 09 Jul 2019

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