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Biochemical analysis

Acute high folic acid treatment in SH-SY5Y cells with and without MTHFR function leads to gene expression changes in epigenetic modifying enzymes, changes in epigenetic marks, and changes in dendritic spine densities

Daniel F. Clark, Rachael Schmelz, Nicole Rogers, Nuri E. Smith, Kimberly R. Shorter

published 07 Jan 2021

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Development and application of high-throughput screens for the discovery of compounds that disrupt ErbB4 signaling: Candidate cancer therapeutics

Richard L. Cullum, Lauren M. Lucas, Jared I. Senfeld, John T. Piazza, Logan T. Neel, Kanupriya Whig, Ling Zhai, Mackenzie H. Harris, Cristina C. Rael, Darby C. Taylor, Laura J. Cook, David P. Kaufmann, Christopher P. Mill, Megan A. Jacobi, Forrest T. Smith, Mark Suto, Robert Bostwick, Ram B. Gupta, Allan E. David, David J. Riese, II

published 30 Dec 2020

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Discovery of potent and specific inhibitors targeting the active site of MMP-9 from the engineered SPINK2 library

Hidenori Yano, Daisuke Nishimiya, Yoshirou Kawaguchi, Masakazu Tamura, Ryuji Hashimoto

published 29 Dec 2020

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Label-free hairpin-like aptamer and EIS-based practical, biostable sensor for acetamiprid detection

Jianhui Zhen, Gang Liang, Ruichun Chen, Wenshen Jia

published 23 Dec 2020

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5,5-Dialkylluciferins are thermal stable substrates for bioluminescence-based detection systems

Ce Shi, Michael P. Killoran, Mary P. Hall, Paul Otto, Monika G. Wood, Ethan Strauss, Lance P. Encell, Thomas Machleidt, Keith V. Wood, Thomas A. Kirkland

published 14 Dec 2020

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Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

Xuan G. Luong, Sarah K. Stevens, Andreas Jekle, Tse-I Lin, Kusum Gupta, Dinah Misner, Sushmita Chanda, Sucheta Mukherjee, Caroline Williams, Antitsa Stoycheva, Lawrence M. Blatt, Leonid N. Beigelman, Julian A. Symons, Pierre Raboisson, David McGowan, Koen Vandyck, Jerome Deval

published 11 Dec 2020

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A novel mouse model of obstructive sleep apnea by bulking agent-induced tongue enlargement results in left ventricular contractile dysfunction

Simon Lebek, Philipp Hegner, Christian Schach, Kathrin Reuthner, Maria Tafelmeier, Lars Siegfried Maier, Michael Arzt, Stefan Wagner

published 10 Dec 2020

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Use of dual-flow bioreactor to develop a simplified model of nervous-cardiovascular systems crosstalk: A preliminary assessment

Nicoletta Marchesi, Annalisa Barbieri, Foroogh Fahmideh, Stefano Govoni, Alice Ghidoni, Gianfranco Parati, Emilio Vanoli, Alessia Pascale, Laura Calvillo

published 30 Nov 2020

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A multivariate, quantitative assay that disentangles key kinetic parameters of primary human T cell function in vitro

Grace L. Huang, Daniel P. Nampe, Jason Yi, Grant B. Gabrelow, Kathleen R. Negri, Alexander Kamb, Han Xu

published 09 Nov 2020

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Commonly used clinical chemistry tests as mortality predictors: Results from two large cohort studies

Lars Lind, Daniela Zanetti, Marieann Högman, Lars Sundman, Erik Ingelsson

published 05 Nov 2020

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In vitro assessment of triterpenoids NVX-207 and betulinyl-bis-sulfamate as a topical treatment for equine skin cancer

Lisa Annabel Weber, Anne Funtan, Reinhard Paschke, Julien Delarocque, Jutta Kalbitz, Jessica Meißner, Karsten Feige, Manfred Kietzmann, Jessika-Maximiliane V. Cavalleri

published 05 Nov 2020

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Rapid SARS-CoV-2 testing in primary material based on a novel multiplex RT-LAMP assay

Bernhard Schermer, Francesca Fabretti, Maximilian Damagnez, Veronica Di Cristanziano, Eva Heger, Sita Arjune, Nathan A. Tanner, Thomas Imhof, Manuel Koch, Alim Ladha, Julia Joung, Jonathan S. Gootenberg, Omar O. Abudayyeh, Volker Burst, Feng Zhang, Florian Klein, Thomas Benzing, Roman-Ulrich Müller

published 02 Nov 2020

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Method feasibility for cross-species testing, qualification, and validation of the Filovirus Animal Nonclinical Group anti-Ebola virus glycoprotein immunoglobulin G enzyme-linked immunosorbent assay for non-human primate serum samples

Nancy A. Niemuth, Thomas L. Rudge Jr., Karen A. Sankovich, Michael S. Anderson, Nicholas D. Skomrock, Christopher S. Badorrek, Carol L. Sabourin

published 29 Oct 2020

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