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Binding analysis

Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome

Paul B. Finn, Devesh Bhimsaria, [ ... ], Peter B. Dervan

Modeling a synthetic aptamer-based riboswitch biosensor sensitive to low hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) concentrations

Michael L. Mayo, Jed O. Eberly, Fiona H. Crocker, Karl J. Indest

Ikaros antagonizes DNA binding by STAT5 in pre-B cells

Beate Heizmann, Stéphanie Le Gras, [ ... ], Philippe Kastner

Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia

Hongbin Wan, Gianluca Selvaggio, Robert A. Pearlstein

Whole egg consumption increases gene expression within the glutathione pathway in the liver of Zucker Diabetic Fatty rats

Joe L. Webb, Amanda E. Bries, [ ... ], Kevin L. Schalinske

Assessing multiple score functions in Rosetta for drug discovery

Shannon T. Smith, Jens Meiler

DNA binding activity of the proximal C-terminal domain of rat DNA topoisomerase IIβ is involved in ICRF-193-induced closed-clamp formation

Shinji Kawano, Kunpei Fujimoto, Kazushi Yasuda, Shogo Ikeda

Dual DNA binding mode of a turn-on red fluorescent probe thiazole coumarin

Sudakshina Ganguly, Debasis Ghosh, [ ... ], Gautam Basu

A radioligand binding assay for the insulin-like growth factor 2 receptor

Pavlo Potalitsyn, Irena Selicharová, [ ... ], Lenka Žáková

The effect of cognitive effort on the sense of agency

Eva Van den Bussche, Maryna Alves, Yannick P. J. Murray, Gethin Hughes

Analysis of opticin binding to collagen fibrils identifies a single binding site in the gap region and a high specificity towards thin heterotypic fibrils containing collagens II, and XI or V/XI

Uwe Hansen, David F. Holmes, Peter Bruckner, Paul N. Bishop

Structure-guided screening strategy combining surface plasmon resonance with nuclear magnetic resonance for identification of small-molecule Argonaute 2 inhibitors

Toshimasa Harumoto, Atsuko Sato, [ ... ], Fumikazu Shinohara

Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms

Beatrice Cameron, Tarik Dabdoubi, [ ... ], Thomas Bouquin

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