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Adjustment of dosage at steady state

Pharmacokinetics and safety after once and twice a day doses of meclizine hydrochloride administered to children with achondroplasia

Hiroshi Kitoh, Masaki Matsushita, [ ... ], Naoki Ishiguro

Quantitation and modeling of post-translational modifications in a therapeutic monoclonal antibody from single- and multiple-dose monkey pharmacokinetic studies using mass spectrometry

Xiaobin Xu, Yu Huang, [ ... ], Ning Li

Operating regimes in a single enzymatic cascade at ensemble-level

Akshay Parundekar, Girija Kalantre, Akshada Khadpekar, Ganesh A. Viswanathan

First-in-human Phase I studies of PRS-080#22, a hepcidin antagonist, in healthy volunteers and patients with chronic kidney disease undergoing hemodialysis

Lutz Renders, Klemens Budde, [ ... ], Louis Matis

A non-randomized trial to assess the safety, tolerability, and pharmacokinetics of posaconazole oral suspension in immunocompromised children with neutropenia

Antonio C. Arrieta, Lillian Sung, [ ... ], Amanda Paschke

The influence of concomitant antiepileptic drugs on lamotrigine serum concentrations in Northwest Chinese Han population with epilepsy

Xiaonian Han, Jing Huang, [ ... ], Xin Zan

Safety, efficacy, and dose response of the maturation inhibitor GSK3532795 (formerly known as BMS-955176) plus tenofovir/emtricitabine once daily in treatment-naive HIV-1-infected adults: Week 24 primary analysis from a randomized Phase IIb trial

Javier Morales-Ramirez, Johannes R. Bogner, [ ... ], Max Lataillade

In healthy volunteers, taking flucloxacillin with food does not compromise effective plasma concentrations in most circumstances

Sharon J. Gardiner, Philip G. Drennan, [ ... ], Evan J. Begg

An open-label, multiple ascending dose study of the anti-CTLA-4 antibody ipilimumab in viremic HIV patients

Elizabeth Colston, Dennis Grasela, [ ... ], Israel Lowy

Pharmacokinetics-adapted Busulfan-based myeloablative conditioning before unrelated umbilical cord blood transplantation for myeloid malignancies in children

Joy Benadiba, Marc Ansari, [ ... ], Henrique Bittencourt

A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: An open-label, parallel group, randomized clinical study

Hyewon Chung, Jaeseong Oh, [ ... ], Jae-Yong Chung

An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers

Sophia E. Airhart, Laura M. Shireman, [ ... ], Kevin D. O’Brien

Estimation of the optimal dosing regimen of escitalopram in dogs: A dose occupancy study with [¹¹C]DASB

Olivia Taylor, Nick Van Laeken, [ ... ], Kathelijne Peremans

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