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Open Access

Retraction

Retraction: Pyrroloquinoline Quinine Inhibits RANKL-Mediated Expression of NFATc1 in Part via Suppression of c-Fos in Mouse Bone Marrow Cells and Inhibits Wear Particle-Induced Osteolysis in Mice

  • The PLOS One Editors

Following the publication of this article, concerns were raised with the results presented in Figs 1, 2, and 5. Specifically,

  • There appear to be multiple repetitive features within and/or between all Fig 1A panels.
  • The Fig 2D NFATc1 panel of [1] appears similar to the Fig 3B NFATc1 panel of [2] despite being used to represent different experimental conditions.
  • The following panels appear to partially overlap despite being used to represent different experimental conditions:
    • Fig 5a of [1] and Fig 4a of [3] when flipped.
    • Fig 5b of [1] and Fig 4b of [3].
    • Fig 5c of [1] and Fig 4d of [3] when flipped.
    • Fig 5e of [1] and Fig 4e of [3].
    • Fig 5f of [1] and Fig 4f of [3].
    • Figs 5i and 5k of [1].

In light of these concerns, which call into question the integrity and reliability of the published results, the PLOS One Editors retract this article.

All authors either did not respond directly or could not be reached.

References

  1. 1. Kong L, Yang C, Yu L, Smith W, Zhu S, Zhu J, et al. RETRACTED: Pyrroloquinoline Quinine Inhibits RANKL-Mediated Expression of NFATc1 in Part via Suppression of c-Fos in Mouse Bone Marrow Cells and Inhibits Wear Particle-Induced Osteolysis in Mice. PLoS One. 2013;8(4):e61013.
  2. 2. Kong L, Zhao Q, Wang X, Zhu J, Hao D, Yang C. Angelica sinensis extract inhibits RANKL-mediated osteoclastogenesis by down-regulated the expression of NFATc1 in mouse bone marrow cells. BMC Complement Altern Med. 2014;14:481. pmid:25496242
  3. 3. Yan Z, Tian X, Zhu J, Lu Z, Yu L, Zhang D, et al. Metformin suppresses UHMWPE particle-induced osteolysis in the mouse calvaria by promoting polarization of macrophages to an anti-inflammatory phenotype. Mol Med. 2018;24(1):20. pmid:30134793

Citation: The PLOS One Editors (2026) Retraction: Pyrroloquinoline Quinine Inhibits RANKL-Mediated Expression of NFATc1 in Part via Suppression of c-Fos in Mouse Bone Marrow Cells and Inhibits Wear Particle-Induced Osteolysis in Mice. PLoS One 21(10): e0360868. https://doi.org/10.1371/journal.pone.0360868

Published: October 19, 2026

Copyright: © 2026 The PLOS One Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.