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Correction: Serum proteomic changes in atopic dermatitis patients treated with cyclosporine

  • The PLOS One Staff

The images for Figs 4 and 5 are incorrectly switched. The image that appears as Fig 4 should be Fig 5, and the image that appears as Fig 5 should be Fig 4. The figure captions appear in the correct order. The authors have provided a corrected version of the figures here.

The publisher apologizes for the error.

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Fig 4. Baseline predictive biomarkers for CsA treatment response.

(A) Heatmap of differentially expressed proteins (DEPs) (fold change <1.5, p < 0.05, q = 0.2) between>EASI 75 good responders (n = 21, red) and <EASI-75 responders (n = 17, green) at baseline, with markers grouped by unsupervised hierarchical clustering based on the 16 DEPs. Yellow color denotes higher and blue color denotes lower mean expression levels. (B) A volcano plot showing the differential level of proteins between>EASI 75 good responders (n = 21) and <EASI-75 responders (n = 17) at baseline. The x-axis represents the value of log2 fold change and the y-axis represents the –log-10 (p-value).

https://doi.org/10.1371/journal.pone.0357330.g004

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Fig 5. ROC model predictive biomarkers for CsA treatment response.

ROC curves of a four-protein based model (black) and curves per individual protein based on odds ratio (OR) of the significant proteins predicting EASI-75 responders. Area under the ROC curve was 0.88 for the final model while individual proteins ranged from 0.6-0.7.

https://doi.org/10.1371/journal.pone.0357330.g005

Reference

  1. 1. Olydam JI, Litman T, Nijsten T, Hoof I, Koopmann W, Pardo LM, et al. Serum proteomic changes in atopic dermatitis patients treated with cyclosporine. PLoS One. 2026;21(4):e0346686. pmid:42008513