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Editorial Note

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Editorial Note: Pathogenic KRAS variants disrupt structure and dynamics: Insights from integrated computational analyses

  • The PLOS One Editors

The PLOS One Editors issue this Editorial Note to inform readers of the following issues that were noted after this article’s [1] publication:

  • The articles cited as References 6, 7, 22, 23, 60, and 61 do not appear to support the respective corresponding cited statements.
  • The article cited as Reference 65 was retracted after [1] was submitted but prior to its acceptance. PLOS considers that this reference is not crucial in supporting the research or conclusions reported in [1], and its corresponding cited statement remains supported by other references.

Corresponding author AU acknowledged the concerns and noted that the article cited as Reference 17 also does not appear to support its corresponding cited statement; however, the Editors consider that the cited statement remains supported by other references.

For the other references identified as not supportive of their corresponding cited statements, the author provided the following alternative references as replacements:

  • The article originally cited as Reference 6 is replaced by the article cited here as [2];
  • The article originally cited as Reference 7 is replaced by the article cited here as [3];
  • The article originally cited as Reference 22 is replaced by the article cited here as [4];
  • The article originally cited as Reference 23 is replaced by the article cited here as [5];
  • The article originally cited as Reference 60 is replaced by the article cited here as [6];
  • The article originally cited as Reference 61 is replaced by the article cited here as [7].

References

  1. 1. Ishaq S, Ali A, Habib O, Usmani SA, Rehman IU, Aziz A, et al. Pathogenic KRAS variants disrupt structure and dynamics: Insights from integrated computational analyses. PLoS One. 2026;21(2):e0341219. pmid:41671225
  2. 2. Simanshu DK, Nissley DV, McCormick F. RAS Proteins and Their Regulators in Human Disease. Cell. 2017;170(1):17–33. pmid:28666118
  3. 3. Bryant KL, Mancias JD, Kimmelman AC, Der CJ. KRAS: feeding pancreatic cancer proliferation. Trends Biochem Sci. 2014;39(2):91–100. pmid:24388967
  4. 4. Lim SW, Tan KJ, Azuraidi OM, Sathiya M, Lim EC, Lai KS, et al. Functional and structural analysis of non-synonymous single nucleotide polymorphisms (nsSNPs) in the MYB oncoproteins associated with human cancer. Sci Rep. 2021;11(1):24206. pmid:34921182
  5. 5. Chai C-Y, Maran S, Thew H-Y, Tan Y-C, Rahman NMANA, Cheng W-H, et al. Predicting Deleterious Non-Synonymous Single Nucleotide Polymorphisms (nsSNPs) of HRAS Gene and In Silico Evaluation of Their Structural and Functional Consequences towards Diagnosis and Prognosis of Cancer. Biology (Basel). 2022;11(11):1604. pmid:36358305
  6. 6. Salmaso V, Moro S. Bridging Molecular Docking to Molecular Dynamics in Exploring Ligand-Protein Recognition Process: An Overview. Front Pharmacol. 2018;9:923. pmid:30186166
  7. 7. De Vivo M, Masetti M, Bottegoni G, Cavalli A. Role of Molecular Dynamics and Related Methods in Drug Discovery. J Med Chem. 2016;59(9):4035–61.

Citation: The PLOS One Editors (2026) Editorial Note: Pathogenic KRAS variants disrupt structure and dynamics: Insights from integrated computational analyses. PLoS One 21(8): e0355660. https://doi.org/10.1371/journal.pone.0355660

Published: August 13, 2026

Copyright: © 2026 The PLOS One Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.